(1S)-CCR2 antagonist 1

Name: (1S)-CCR2 antagonist 1
Brand: MedChemExpress
SKU: HY-112792A
Rating: 4.5 (1 reviews)

Cat. No.: HY-112792A Purity: 98.03%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a K_i of 2.4 nM.

For research use only. We do not sell to patients.

(1S)-CCR2 antagonist 1 Chemical Structure

CAS No. : 1683534-97-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
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200 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (1S)-CCR2 antagonist 1:

CCR2 antagonist 1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a K_i of 2.4 nM^[1].

In Vitro

The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), K_i=2.4 nM; RT=714 min)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

549.47

Formula

C₂₈H₃₂BrF₃N₂O

CAS No.

1683534-97-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (227.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8199 mL	9.0997 mL	18.1994 mL
5 mM	0.3640 mL	1.8199 mL	3.6399 mL
10 mM	0.1820 mL	0.9100 mL	1.8199 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.03%

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Data Sheet (270 KB) SDS (251 KB)

COA (248 KB) RP-HPLC (278 KB)

Handling Instructions (2659 KB)

References

[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8199 mL	9.0997 mL	18.1994 mL	45.4984 mL
	5 mM	0.3640 mL	1.8199 mL	3.6399 mL	9.0997 mL
	10 mM	0.1820 mL	0.9100 mL	1.8199 mL	4.5498 mL
	15 mM	0.1213 mL	0.6066 mL	1.2133 mL	3.0332 mL
	20 mM	0.0910 mL	0.4550 mL	0.9100 mL	2.2749 mL
	25 mM	0.0728 mL	0.3640 mL	0.7280 mL	1.8199 mL
	30 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5166 mL
	40 mM	0.0455 mL	0.2275 mL	0.4550 mL	1.1375 mL
	50 mM	0.0364 mL	0.1820 mL	0.3640 mL	0.9100 mL
	60 mM	0.0303 mL	0.1517 mL	0.3033 mL	0.7583 mL
	80 mM	0.0227 mL	0.1137 mL	0.2275 mL	0.5687 mL
	100 mM	0.0182 mL	0.0910 mL	0.1820 mL	0.4550 mL