2′,2′-Difluorodeoxyuridine (Synonyms: dFdU; 2',2'-Difluoro-2'-deoxyuridine)

Cat. No.: HY-138253 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro.

For research use only. We do not sell to patients.

2′,2′-Difluorodeoxyuridine Chemical Structure

CAS No. : 114248-23-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 88	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 196	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of 2′,2′-Difluorodeoxyuridine:

2′,2′-Difluorodeoxyuridine-¹³C,¹⁵N₂ Get quote
2′,2′-Difluorodeoxyuridine (Standard) Get quote

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Purity & Documentation
References
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Description

Molecular Weight

264.18

Formula

C₉H₁₀F₂N₂O₅

CAS No.

114248-23-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)C=CC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (473.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (378.53 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7853 mL	18.9265 mL	37.8530 mL
5 mM	0.7571 mL	3.7853 mL	7.5706 mL
10 mM	0.3785 mL	1.8926 mL	3.7853 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (251 KB) HNMR (271 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58(2):219-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.7853 mL	18.9265 mL	37.8530 mL	94.6325 mL
	5 mM	0.7571 mL	3.7853 mL	7.5706 mL	18.9265 mL
	10 mM	0.3785 mL	1.8926 mL	3.7853 mL	9.4632 mL
	15 mM	0.2524 mL	1.2618 mL	2.5235 mL	6.3088 mL
	20 mM	0.1893 mL	0.9463 mL	1.8926 mL	4.7316 mL
	25 mM	0.1514 mL	0.7571 mL	1.5141 mL	3.7853 mL
	30 mM	0.1262 mL	0.6309 mL	1.2618 mL	3.1544 mL
	40 mM	0.0946 mL	0.4732 mL	0.9463 mL	2.3658 mL
	50 mM	0.0757 mL	0.3785 mL	0.7571 mL	1.8926 mL
	60 mM	0.0631 mL	0.3154 mL	0.6309 mL	1.5772 mL
	80 mM	0.0473 mL	0.2366 mL	0.4732 mL	1.1829 mL
	100 mM	0.0379 mL	0.1893 mL	0.3785 mL	0.9463 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

2′,2′-Difluorodeoxyuridine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2′,2′-Difluorodeoxyuridine114248-23-6dFdU 2',2'-Difluoro-2'-deoxyuridineDrug MetaboliteGemcitabineradiosensitisingECV304H292Inhibitorinhibitorinhibit

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