2-Deacetoxy-taxinine J

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2-Deacetoxy-taxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata..

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2-Deacetoxy-taxinine J Chemical Structure

CAS No. : 119347-14-7

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Description

2-Deacetoxy-taxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata.^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	9.7 μM Compound: 2	Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
A549	IC₅₀	7.1 μM Compound: 2	Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
A549	IC₅₀	9.4 μM Compound: 2	Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
HCT-8	IC₅₀	11 μM Compound: 2	Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
HEK293	IC₅₀	> 50 μM Compound: 1, 2-DAT-J	Cytotoxicity against HEK293 cells after 18 hrs by MTT assay Cytotoxicity against HEK293 cells after 18 hrs by MTT assay	[PMID: 19446930]
HeLa	IC₅₀	5.7 μM Compound: 12	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 dye based assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 dye based assay	[PMID: 28240909]
HepG2	IC₅₀	> 25 μM Compound: 2	Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
MCF7	IC₅₀	> 25 μM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
MCF7	IC₅₀	20 μM Compound: 1, 2-DAT-J	Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay	[PMID: 19446930]
MDA-MB-231	IC₅₀	10 μM Compound: 1, 2-DAT-J	Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay	[PMID: 19446930]
NIH3T3	IC₅₀	15 μM Compound: 2	Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
SW480	IC₅₀	> 25 μM Compound: 2	Antiproliferative activity against human SW480 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human SW480 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]

Molecular Weight

650.76

Formula

C₃₇H₄₆O₁₀

CAS No.

119347-14-7

SMILES

C[C@]([C@](C1=C)([H])C[C@@](C[C@@H]2OC(C)=O)([H])C3(C)C)([C@H](C[C@@H]1OC(/C=C/C4=CC=CC=C4)=O)OC(C)=O)[C@H]([C@@H](C3=C2C)OC(C)=O)OC(C)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)