2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. 2'-Deoxyadenosine-5'-triphosphate trisodium

2'-Deoxyadenosine-5'-triphosphate trisodium  (Synonyms: dATP trisodium)

Cat. No.: HY-136648A Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

For research use only. We do not sell to patients.

2'-Deoxyadenosine-5'-triphosphate trisodium Chemical Structure

2'-Deoxyadenosine-5'-triphosphate trisodium Chemical Structure

CAS No. : 54680-12-5

Size Price Stock Quantity
25 mg USD 60 In-stock
50 mg USD 100 In-stock
100 mg USD 160 In-stock
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2'-Deoxyadenosine-5'-triphosphate trisodium Related Antibodies

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Description

2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase[1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

557.13

Formula

C10H13N5Na3O12P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H](O1)CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)C[C@@H]1N2C3=NC=NC(N)=C3N=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (448.73 mM; Need ultrasonic)

DMSO : 4.55 mg/mL (8.17 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7949 mL 8.9746 mL 17.9491 mL
5 mM 0.3590 mL 1.7949 mL 3.5898 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (179.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (252 KB) HNMR (292 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.7949 mL 8.9746 mL 17.9491 mL 44.8728 mL
5 mM 0.3590 mL 1.7949 mL 3.5898 mL 8.9746 mL
H2O 10 mM 0.1795 mL 0.8975 mL 1.7949 mL 4.4873 mL
15 mM 0.1197 mL 0.5983 mL 1.1966 mL 2.9915 mL
20 mM 0.0897 mL 0.4487 mL 0.8975 mL 2.2436 mL
25 mM 0.0718 mL 0.3590 mL 0.7180 mL 1.7949 mL
30 mM 0.0598 mL 0.2992 mL 0.5983 mL 1.4958 mL
40 mM 0.0449 mL 0.2244 mL 0.4487 mL 1.1218 mL
50 mM 0.0359 mL 0.1795 mL 0.3590 mL 0.8975 mL
60 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7479 mL
80 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5609 mL
100 mM 0.0179 mL 0.0897 mL 0.1795 mL 0.4487 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2'-Deoxyadenosine-5'-triphosphate trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyadenosine-5'-triphosphate trisodium54680-12-5dATP trisodiumEndogenous MetaboliteDNA/RNA SynthesisInhibitorinhibitorinhibit

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