2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 2-Phenyl-2-(1-piperidinyl)propane

2-Phenyl-2-(1-piperidinyl)propane 

Cat. No.: HY-W040468 Purity: 99.81%
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2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2-(1-piperidinyl)propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM).

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2-Phenyl-2-(1-piperidinyl)propane Chemical Structure

2-Phenyl-2-(1-piperidinyl)propane Chemical Structure

CAS No. : 92321-29-4

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2-Phenyl-2-(1-piperidinyl)propane Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2-(1-piperidinyl)propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM)[1].

IC50 & Target[1]

CYP2B6

5.1 μM (IC50)

CYP2B6

5.6 μM (Ki)

CYP2D6

74 μM (IC50)

CYP3A

200 μM (IC50)

CYP1A2

>300 μM (IC50)

CYP2A6

>300 μM (IC50)

CYP2C8

>300 μM (IC50)

CYP2C9

>300 μM (EC50)

CYP2C19

>300 μM (IC50)

CYP2E1

>300 μM (IC50)

Molecular Weight

203.32

Formula

C14H21N
CAS No.
Appearance

Liquid (Density: 0.969±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

CC(N1CCCCC1)(C2=CC=CC=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (245.92 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9184 mL 24.5918 mL 49.1836 mL
5 mM 0.9837 mL 4.9184 mL 9.8367 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9184 mL 24.5918 mL 49.1836 mL 122.9589 mL
5 mM 0.9837 mL 4.9184 mL 9.8367 mL 24.5918 mL
10 mM 0.4918 mL 2.4592 mL 4.9184 mL 12.2959 mL
15 mM 0.3279 mL 1.6395 mL 3.2789 mL 8.1973 mL
20 mM 0.2459 mL 1.2296 mL 2.4592 mL 6.1479 mL
25 mM 0.1967 mL 0.9837 mL 1.9673 mL 4.9184 mL
30 mM 0.1639 mL 0.8197 mL 1.6395 mL 4.0986 mL
40 mM 0.1230 mL 0.6148 mL 1.2296 mL 3.0740 mL
50 mM 0.0984 mL 0.4918 mL 0.9837 mL 2.4592 mL
60 mM 0.0820 mL 0.4099 mL 0.8197 mL 2.0493 mL
80 mM 0.0615 mL 0.3074 mL 0.6148 mL 1.5370 mL
100 mM 0.0492 mL 0.2459 mL 0.4918 mL 1.2296 mL
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2-Phenyl-2-(1-piperidinyl)propane Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Phenyl-2-(1-piperidinyl)propane92321-29-4Cytochrome P450CYPsReversibleCYP2B6CYP2D6CYP3AInhibitorinhibitorinhibit

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