D-Mannosamine hydrochloride (Synonyms: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride)

Name: D-Mannosamine hydrochloride
Brand: MedChemExpress
SKU: HY-W021425
Rating: 4.5 (1 reviews)

Cat. No.: HY-W021425 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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D-Mannosamine hydrochloride is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells.

For research use only. We do not sell to patients.

D-Mannosamine hydrochloride Chemical Structure

CAS No. : 5505-63-5

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Based on 1 publication(s) in Google Scholar

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Description

D-Mannosamine hydrochloride is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells^[1].

Molecular Weight

215.63

Formula

C₆H₁₄ClNO₅

CAS No.

5505-63-5

Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.[H]Cl

Structure Classification

Saccharides

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (463.76 mM)

DMSO : 25 mg/mL (115.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6376 mL	23.1879 mL	46.3757 mL
5 mM	0.9275 mL	4.6376 mL	9.2751 mL
10 mM	0.4638 mL	2.3188 mL	4.6376 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (244 KB) SDS (393 KB)

COA (245 KB) HNMR (125 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.6376 mL	23.1879 mL	46.3757 mL	115.9393 mL
	5 mM	0.9275 mL	4.6376 mL	9.2751 mL	23.1879 mL
	10 mM	0.4638 mL	2.3188 mL	4.6376 mL	11.5939 mL
	15 mM	0.3092 mL	1.5459 mL	3.0917 mL	7.7293 mL
	20 mM	0.2319 mL	1.1594 mL	2.3188 mL	5.7970 mL
	25 mM	0.1855 mL	0.9275 mL	1.8550 mL	4.6376 mL
	30 mM	0.1546 mL	0.7729 mL	1.5459 mL	3.8646 mL
	40 mM	0.1159 mL	0.5797 mL	1.1594 mL	2.8985 mL
	50 mM	0.0928 mL	0.4638 mL	0.9275 mL	2.3188 mL
	60 mM	0.0773 mL	0.3865 mL	0.7729 mL	1.9323 mL
	80 mM	0.0580 mL	0.2898 mL	0.5797 mL	1.4492 mL
	100 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1594 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

D-Mannosamine hydrochloride Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Mannosamine5505-63-5(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanalOthersInhibitorinhibitorinhibit

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D-Mannosamine hydrochloride (Synonyms: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride)

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D-Mannosamine hydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

D-Mannosamine hydrochloride Related Classifications

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