2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. 3,5-Difluoro-L-tyrosine

3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs).

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3,5-Difluoro-L-tyrosine Chemical Structure

3,5-Difluoro-L-tyrosine Chemical Structure

CAS No. : 73246-30-7

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Description

3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs)[1].

In Vitro

3,5-Difluoro-L-tyrosine (F2Y) is a fluorinated tyrosine analog. 3,5-Difluoro-L-tyrosine is compatible with every aspect of library synthesis, screening, and sequence identification. 3,5-Difluoro-L-tyrosine is a good functional mimic of tyrosine, in terms of binding to the active site of PTPs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

217.17

Formula

C9H9F2NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CC(F)=C(O)C(F)=C1)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 7 mg/mL (32.23 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6047 mL 23.0234 mL 46.0469 mL
5 mM 0.9209 mL 4.6047 mL 9.2094 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6047 mL 23.0234 mL 46.0469 mL 115.1172 mL
5 mM 0.9209 mL 4.6047 mL 9.2094 mL 23.0234 mL
10 mM 0.4605 mL 2.3023 mL 4.6047 mL 11.5117 mL
15 mM 0.3070 mL 1.5349 mL 3.0698 mL 7.6745 mL
20 mM 0.2302 mL 1.1512 mL 2.3023 mL 5.7559 mL
25 mM 0.1842 mL 0.9209 mL 1.8419 mL 4.6047 mL
30 mM 0.1535 mL 0.7674 mL 1.5349 mL 3.8372 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3,5-Difluoro-L-tyrosine Related Classifications

Keywords:

3,5-Difluoro-L-tyrosine73246-30-7PhosphatasePTPfluorinatedtyrosinesubstratetyrosinase-resistantmimeticInhibitorinhibitorinhibit

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