3,5-Difluoro-L-tyrosine

Name: 3,5-Difluoro-L-tyrosine
Brand: MedChemExpress
SKU: HY-136595
Rating: 4.5 (1 reviews)

Cat. No.: HY-136595 Purity: 98.39%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs).

For research use only. We do not sell to patients.

3,5-Difluoro-L-tyrosine Chemical Structure

CAS No. : 73246-30-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs)^[1].

In Vitro

3,5-Difluoro-L-tyrosine (F2Y) is a fluorinated tyrosine analog. 3,5-Difluoro-L-tyrosine is compatible with every aspect of library synthesis, screening, and sequence identification. 3,5-Difluoro-L-tyrosine is a good functional mimic of tyrosine, in terms of binding to the active site of PTPs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

217.17

Formula

C₉H₉F₂NO₃

CAS No.

73246-30-7

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CC(F)=C(O)C(F)=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 7 mg/mL (32.23 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6047 mL	23.0234 mL	46.0469 mL
5 mM	0.9209 mL	4.6047 mL	9.2094 mL
10 mM	0.4605 mL	2.3023 mL	4.6047 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.39%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (247 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Bhaskar Gopishetty, et al. Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases. Org Lett. 2008 Oct 16;10(20):4605-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.6047 mL	23.0234 mL	46.0469 mL	115.1172 mL
	5 mM	0.9209 mL	4.6047 mL	9.2094 mL	23.0234 mL
	10 mM	0.4605 mL	2.3023 mL	4.6047 mL	11.5117 mL
	15 mM	0.3070 mL	1.5349 mL	3.0698 mL	7.6745 mL
	20 mM	0.2302 mL	1.1512 mL	2.3023 mL	5.7559 mL
	25 mM	0.1842 mL	0.9209 mL	1.8419 mL	4.6047 mL
	30 mM	0.1535 mL	0.7674 mL	1.5349 mL	3.8372 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.