3-Hydroxy-4-aminopyridine

Name: 3-Hydroxy-4-aminopyridine
Brand: MedChemExpress
SKU: HY-W008188
Rating: 4.5 (1 reviews)

Cat. No.: HY-W008188 Purity: 98.75%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Hydroxy-4-aminopyridine is an endogenous metabolite.

For research use only. We do not sell to patients.

3-Hydroxy-4-aminopyridine Chemical Structure

CAS No. : 52334-53-9

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Purity & Documentation
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Description

3-Hydroxy-4-aminopyridine is an endogenous metabolite.

Molecular Weight

110.11

Formula

C₅H₆N₂O

CAS No.

52334-53-9

Appearance

Solid

Color

White to light brown

SMILES

OC1=C(N)C=CN=C1

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 16.67 mg/mL (151.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.0818 mL	45.4091 mL	90.8183 mL
5 mM	1.8164 mL	9.0818 mL	18.1637 mL
10 mM	0.9082 mL	4.5409 mL	9.0818 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (18.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (18.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 3

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.67 mg/mL (15.17 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.75%

Select Batch:

Data Sheet (245 KB) SDS (393 KB)

COA (250 KB) HNMR (248 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	9.0818 mL	45.4091 mL	90.8183 mL	227.0457 mL
	5 mM	1.8164 mL	9.0818 mL	18.1637 mL	45.4091 mL
	10 mM	0.9082 mL	4.5409 mL	9.0818 mL	22.7046 mL
	15 mM	0.6055 mL	3.0273 mL	6.0546 mL	15.1364 mL
	20 mM	0.4541 mL	2.2705 mL	4.5409 mL	11.3523 mL
	25 mM	0.3633 mL	1.8164 mL	3.6327 mL	9.0818 mL
	30 mM	0.3027 mL	1.5136 mL	3.0273 mL	7.5682 mL
	40 mM	0.2270 mL	1.1352 mL	2.2705 mL	5.6761 mL
	50 mM	0.1816 mL	0.9082 mL	1.8164 mL	4.5409 mL
	60 mM	0.1514 mL	0.7568 mL	1.5136 mL	3.7841 mL
	80 mM	0.1135 mL	0.5676 mL	1.1352 mL	2.8381 mL
	100 mM	0.0908 mL	0.4541 mL	0.9082 mL	2.2705 mL