2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3’-O-(2-Methoxyethyl)guanosine

3’-O-(2-Methoxyethyl)guanosine 

Cat. No.: HY-152493 Purity: 98.90%
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3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).

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3’-O-(2-Methoxyethyl)guanosine Chemical Structure

3’-O-(2-Methoxyethyl)guanosine Chemical Structure

CAS No. : 256224-03-0

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Based on 1 publication(s) in Google Scholar

3’-O-(2-Methoxyethyl)guanosine Related Antibodies

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Description

3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Molecular Weight

341.32

Formula

C13H19N5O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](OCCOC)[C@@H](O)[C@H](N(C=N2)C3=C2C(NC(N)=N3)=O)O1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (256.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9298 mL 14.6490 mL 29.2980 mL
5 mM 0.5860 mL 2.9298 mL 5.8596 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9298 mL 14.6490 mL 29.2980 mL 73.2450 mL
5 mM 0.5860 mL 2.9298 mL 5.8596 mL 14.6490 mL
10 mM 0.2930 mL 1.4649 mL 2.9298 mL 7.3245 mL
15 mM 0.1953 mL 0.9766 mL 1.9532 mL 4.8830 mL
20 mM 0.1465 mL 0.7325 mL 1.4649 mL 3.6623 mL
25 mM 0.1172 mL 0.5860 mL 1.1719 mL 2.9298 mL
30 mM 0.0977 mL 0.4883 mL 0.9766 mL 2.4415 mL
40 mM 0.0732 mL 0.3662 mL 0.7325 mL 1.8311 mL
50 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4649 mL
60 mM 0.0488 mL 0.2442 mL 0.4883 mL 1.2208 mL
80 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.9156 mL
100 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7325 mL
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3’-O-(2-Methoxyethyl)guanosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3’-O-(2-Methoxyethyl)guanosine256224-03-0Nucleoside Antimetabolite/Analogimmunostimulatorytype I interferonsantiviralInhibitorinhibitorinhibit

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