2. Others Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. Isotope-Labeled Compounds Topoisomerase ADC Cytotoxin
  4. (4-NH2)-Exatecan-d5

(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

(4-NH2)-Exatecan-d5 Chemical Structure

(4-NH2)-Exatecan-d5 Chemical Structure

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Other Forms of (4-NH2)-Exatecan-d5:

(4-NH2)-Exatecan-d5 Related Antibodies

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Description

(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan[1]. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
(4-NH2)-Exatecan contains a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue, characterized by the addition of an amino (NH2) functional group at the 4th position of the parent molecule[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(4-NH2)-Exatecan-d5 Related Antibodies
Molecular Weight

408.46

Formula

C23H16D5N3O4
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)C([2H])([2H])C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (81.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4482 mL 12.2411 mL 24.4822 mL
5 mM 0.4896 mL 2.4482 mL 4.8964 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4482 mL 12.2411 mL 24.4822 mL 61.2055 mL
5 mM 0.4896 mL 2.4482 mL 4.8964 mL 12.2411 mL
10 mM 0.2448 mL 1.2241 mL 2.4482 mL 6.1206 mL
15 mM 0.1632 mL 0.8161 mL 1.6321 mL 4.0804 mL
20 mM 0.1224 mL 0.6121 mL 1.2241 mL 3.0603 mL
25 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4482 mL
30 mM 0.0816 mL 0.4080 mL 0.8161 mL 2.0402 mL
40 mM 0.0612 mL 0.3060 mL 0.6121 mL 1.5301 mL
50 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
60 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0201 mL
80 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7651 mL
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(4-NH2)-Exatecan-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(4-NH2)-Exatecan-d5Isotope-Labeled CompoundsTopoisomeraseADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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