7-Deaza-2'-deoxy-7-iodoadenosine

Name: 7-Deaza-2'-deoxy-7-iodoadenosine
Brand: MedChemExpress
SKU: HY-W048490
Rating: 4.5 (1 reviews)

Cat. No.: HY-W048490 Purity: 99.71%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.

For research use only. We do not sell to patients.

7-Deaza-2'-deoxy-7-iodoadenosine Chemical Structure

CAS No. : 166247-63-8

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100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of 7-Deaza-2'-deoxy-7-iodoadenosine:

(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine^[1].

Molecular Weight

376.15

Formula

C₁₁H₁₃IN₄O₃

CAS No.

166247-63-8

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1C(I)=CN2[C@H]3C[C@H](O)[C@@H](CO)O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (132.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6585 mL	13.2926 mL	26.5851 mL
5 mM	0.5317 mL	2.6585 mL	5.3170 mL
10 mM	0.2659 mL	1.3293 mL	2.6585 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.71%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (255 KB) HNMR (205 KB) RP-HPLC (143 KB) MS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Frank Seela, et al. Oligonucleotides Containing 7‐Deazaadenines: The Influence of the 7‐Substituent Chain Length and Charge on the Duplex Stability. Research Article

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6585 mL	13.2926 mL	26.5851 mL	66.4628 mL
	5 mM	0.5317 mL	2.6585 mL	5.3170 mL	13.2926 mL
	10 mM	0.2659 mL	1.3293 mL	2.6585 mL	6.6463 mL
	15 mM	0.1772 mL	0.8862 mL	1.7723 mL	4.4309 mL
	20 mM	0.1329 mL	0.6646 mL	1.3293 mL	3.3231 mL
	25 mM	0.1063 mL	0.5317 mL	1.0634 mL	2.6585 mL
	30 mM	0.0886 mL	0.4431 mL	0.8862 mL	2.2154 mL
	40 mM	0.0665 mL	0.3323 mL	0.6646 mL	1.6616 mL
	50 mM	0.0532 mL	0.2659 mL	0.5317 mL	1.3293 mL
	60 mM	0.0443 mL	0.2215 mL	0.4431 mL	1.1077 mL
	80 mM	0.0332 mL	0.1662 mL	0.3323 mL	0.8308 mL
	100 mM	0.0266 mL	0.1329 mL	0.2659 mL	0.6646 mL