1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
  3. 7-Iodo-2',3'-dideoxy-7-deazaadenosine

7-Iodo-2',3'-dideoxy-7-deazaadenosine 

Cat. No.: HY-W048480 Purity: 98.93%
Data Sheet SDS COA Handling Instructions Technical Support

7-Iodo-2',3'-dideoxy-7-deazaadenosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions.

For research use only. We do not sell to patients.

7-Iodo-2',3'-dideoxy-7-deazaadenosine Chemical Structure

7-Iodo-2',3'-dideoxy-7-deazaadenosine Chemical Structure

CAS No. : 114748-70-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 121 In-stock
Solution
10 mM * 1 mL in DMSO USD 127 In-stock
Solid
5 mg USD 116 In-stock
10 mg USD 189 In-stock
25 mg USD 357 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

7-Iodo-2',3'-dideoxy-7-deazaadenosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions[1].

Molecular Weight

360.15

Formula

C11H13IN4O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1O[C@@H](N2C(N=CN=C3N)=C3C(I)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (347.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7766 mL 13.8831 mL 27.7662 mL
5 mM 0.5553 mL 2.7766 mL 5.5532 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7766 mL 13.8831 mL 27.7662 mL 69.4155 mL
5 mM 0.5553 mL 2.7766 mL 5.5532 mL 13.8831 mL
10 mM 0.2777 mL 1.3883 mL 2.7766 mL 6.9416 mL
15 mM 0.1851 mL 0.9255 mL 1.8511 mL 4.6277 mL
20 mM 0.1388 mL 0.6942 mL 1.3883 mL 3.4708 mL
25 mM 0.1111 mL 0.5553 mL 1.1106 mL 2.7766 mL
30 mM 0.0926 mL 0.4628 mL 0.9255 mL 2.3139 mL
40 mM 0.0694 mL 0.3471 mL 0.6942 mL 1.7354 mL
50 mM 0.0555 mL 0.2777 mL 0.5553 mL 1.3883 mL
60 mM 0.0463 mL 0.2314 mL 0.4628 mL 1.1569 mL
80 mM 0.0347 mL 0.1735 mL 0.3471 mL 0.8677 mL
100 mM 0.0278 mL 0.1388 mL 0.2777 mL 0.6942 mL
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Product Name:
7-Iodo-2',3'-dideoxy-7-deazaadenosine
Cat. No.:
HY-W048480
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