2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Alagebrium chloride

Alagebrium chloride  (Synonyms: ALT711)

Cat. No.: HY-106024B Purity: 99.93%
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Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor.

For research use only. We do not sell to patients.

Alagebrium chloride Chemical Structure

Alagebrium chloride Chemical Structure

CAS No. : 341028-37-3

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10 mM * 1 mL in DMSO
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Alagebrium chloride:

Alagebrium chloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Alagebrium chloride

WB

    Alagebrium chloride purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2019 Mar 15;11(3):1569-1580.  [Abstract]

    Western blotting analysis of TSP-1 protein expression, and results show that TSP-1 expression in HUVECs treated with ALT-711 under CML-BSA condition is enhanced by miR-27b inhibitor.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor.

    IC50 & Target

    AGE[1]
    In Vitro

    Alagebrium chloride is an advanced glycation end product (AGE) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Alagebrium chloride Related Antibodies
    In Vivo

    Blood pressure is not affected by treatment with Alagebrium.? In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice[1]. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment.? A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    267.77

    Formula

    C13H14ClNOS
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=CC=CC=C1)C[N+]2=CSC(C)=C2C.[Cl-]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (186.73 mM; Need ultrasonic)

    DMSO : ≥ 25 mg/mL (93.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7345 mL 18.6727 mL 37.3455 mL
    5 mM 0.7469 mL 3.7345 mL 7.4691 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    C2

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (9.34 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (9.34 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (373.45 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.93%

    SDS (393 KB)

    COA (253 KB) LCMS (110 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [2]

    Human aortic endothelial cells (HAECs) are seeded on decellularized matrices derived from the abdominal aorta (AAo) of Zucker lean (ZL), obese (ZO), and diabetic (ZD) rats with or without Alagebrium (ALT-711) (20 μg/mL in Dulbecco's PBS with 1× antibiotic-antimycotic). Experiments are performed when cells reach 80 to 90% confluence. Flow chambers are sealed to the HAEC monolayers via a vacuum network. Flow is driven by a Masterflex L/S peristaltic pump in a humidified chamber heated to 37°C for 4 h. Leibovitz-15 medium, supplemented with 10% FBS, endothelial BulletKit, and 1× antibiotic-antimycotic solution, is used as the flow medium to maintain pH in the absence of CO2[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    RAGE apoE mice are randomized to be treated with Alagebrium (1 mg/kg/day by gavage), or no treatment (n=20/group). After 20 weeks of diabetes, mice are placed into individual metabolic cages for 24 h and urine is collected. Body weight as well as fluid and food intake are recorded. Urinary albumin excretion is estimated in urine samples by a mouse albumin enzyme-linked immunosorbent assay (ELISA) kit according to the kit protocol. Urinary and serum creatinine concentrations are measured by high-performance liquid chromatography (HPLC). Systolic blood pressure is assessed by a noninvasive tail cuff method in conscious mice at the end of the study[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.7345 mL 18.6727 mL 37.3455 mL 93.3637 mL
    5 mM 0.7469 mL 3.7345 mL 7.4691 mL 18.6727 mL
    10 mM 0.3735 mL 1.8673 mL 3.7345 mL 9.3364 mL
    15 mM 0.2490 mL 1.2448 mL 2.4897 mL 6.2242 mL
    20 mM 0.1867 mL 0.9336 mL 1.8673 mL 4.6682 mL
    25 mM 0.1494 mL 0.7469 mL 1.4938 mL 3.7345 mL
    30 mM 0.1245 mL 0.6224 mL 1.2448 mL 3.1121 mL
    40 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3341 mL
    50 mM 0.0747 mL 0.3735 mL 0.7469 mL 1.8673 mL
    60 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5561 mL
    80 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1670 mL
    H2O 100 mM 0.0373 mL 0.1867 mL 0.3735 mL 0.9336 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Alagebrium chloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Alagebrium341028-37-3ALT711ALT 711ALT-711Endogenous MetaboliteInhibitorinhibitorinhibit

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