2. GPCR/G Protein
  3. GHSR
  4. Anamorelin hydrochloride

Anamorelin hydrochloride  (Synonyms: RC-1291 hydrochloride; ONO-7643 hydrochloride)

Cat. No.: HY-14734A Purity: 99.59%
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Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia.

For research use only. We do not sell to patients.

Anamorelin hydrochloride Chemical Structure

Anamorelin hydrochloride Chemical Structure

CAS No. : 861998-00-7

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10 mM * 1 mL in DMSO
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Based on 9 publication(s) in Google Scholar

Other Forms of Anamorelin hydrochloride:

Anamorelin hydrochloride Related Antibodies

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Description

Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia[1][2].

IC50 & Target

Ki: 0.7 nM (Ghrelin receptor)[1]
EC50: 0.74 nM (Ghrelin receptor)[1]
In Vitro

Anamorelin (0.01 nM-10 μM; 15 min) hydrochloride stimulates growth hormone release in a dose-dependent manner in rat pituitary cells, with an EC50 of 1.5 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anamorelin hydrochloride Related Antibodies
In Vivo

Anamorelin (3-30 mg/kg; oral administration; 6 days) hydrochloride increases food intake and body weight in rats in a dose-dependent manner[1].
Anamorelin (3.5 mg/kg; oral administration; 1-7 days) hydrochloride significantly elevates the levels of growth hormone and insulin-like growth factor-1 in pigs[1].
Anamorelin (3-30 mg/kg; oral administration; 28 days) hydrochloride does not promote tumor growth in a nude mouse model of lung cancer xenografts, but increases the body weight of nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (nu/nu, Harlan) (18.4-26.6 g, 9-10 weeks old) treated A549 cells[2]
Dosage: 3, 10 and 30 mg/kg
Administration: Oral administration (p.o.); 28 day
Result: Did not promote tumor growth in the murine NSCLC xenograft model.
Significantly increased the percentage of mean body weight gain at the end of treatment at doses of 10 and 30 mg/kg compared with controls.
Significantly increased peak plasma levels of murine growth hormone (mGH), while peak murine insulin-like growth factor-1 (mIGF-1) levels were slightly elevated but not statistically significant.
Were well tolerated.
Clinical Trial
Molecular Weight

583.16

Formula

C31H43ClN6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (171.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (85.74 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7148 mL 8.5740 mL 17.1480 mL
5 mM 0.3430 mL 1.7148 mL 3.4296 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (8.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

  • Protocol 2

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.59%

SDS (581 KB)

COA (253 KB) HNMR (543 KB) RP-HPLC (267 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.7148 mL 8.5740 mL 17.1480 mL 42.8699 mL
5 mM 0.3430 mL 1.7148 mL 3.4296 mL 8.5740 mL
10 mM 0.1715 mL 0.8574 mL 1.7148 mL 4.2870 mL
15 mM 0.1143 mL 0.5716 mL 1.1432 mL 2.8580 mL
20 mM 0.0857 mL 0.4287 mL 0.8574 mL 2.1435 mL
25 mM 0.0686 mL 0.3430 mL 0.6859 mL 1.7148 mL
30 mM 0.0572 mL 0.2858 mL 0.5716 mL 1.4290 mL
40 mM 0.0429 mL 0.2143 mL 0.4287 mL 1.0717 mL
50 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8574 mL
60 mM 0.0286 mL 0.1429 mL 0.2858 mL 0.7145 mL
80 mM 0.0214 mL 0.1072 mL 0.2143 mL 0.5359 mL
DMSO 100 mM 0.0171 mL 0.0857 mL 0.1715 mL 0.4287 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Anamorelin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anamorelin861998-00-7RC-1291ONO-7643RC1291RC 1291ONO7643ONO 7643GHSRGrowth hormone secretagogue receptorGhrelin receptorrat pituitary cellsA549GHIGF-1Inhibitorinhibitorinhibit

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