2. Neuronal Signaling
  3. Amyloid-β
  4. BF 227

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

For research use only. We do not sell to patients.

BF 227 Chemical Structure

BF 227 Chemical Structure

CAS No. : 845647-80-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 440 In-stock
Solution
10 mM * 1 mL in DMSO USD 440 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

BF 227 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

IC50 & Target

Ki: 4.3 nM (Aβ1-42)[1].
In Vitro

BF-227 has a high binding affinity for Aβ1-42 fibrils. The Ki value for Aβ1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.3±1.3 nM in BF-227 (Kd value of [125I]BF-180: 10.8±1.5 nM)[1]. [11C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BF 227 Related Antibodies
Molecular Weight

333.38

Formula

C16H16FN3O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (187.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9996 mL 14.9979 mL 29.9958 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9996 mL 14.9979 mL 29.9958 mL 74.9895 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL 14.9979 mL
10 mM 0.3000 mL 1.4998 mL 2.9996 mL 7.4990 mL
15 mM 0.2000 mL 0.9999 mL 1.9997 mL 4.9993 mL
20 mM 0.1500 mL 0.7499 mL 1.4998 mL 3.7495 mL
25 mM 0.1200 mL 0.5999 mL 1.1998 mL 2.9996 mL
30 mM 0.1000 mL 0.4999 mL 0.9999 mL 2.4997 mL
40 mM 0.0750 mL 0.3749 mL 0.7499 mL 1.8747 mL
50 mM 0.0600 mL 0.3000 mL 0.5999 mL 1.4998 mL
60 mM 0.0500 mL 0.2500 mL 0.4999 mL 1.2498 mL
80 mM 0.0375 mL 0.1875 mL 0.3749 mL 0.9374 mL
100 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7499 mL
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BF 227 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BF 227845647-80-5BF227BF-227Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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