2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Benzetimide hydrochloride

Benzetimide hydrochloride  (Synonyms: R4929)

Cat. No.: HY-B1547A Purity: 99.44%
COA Handling Instructions

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Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist.

For research use only. We do not sell to patients.

Benzetimide hydrochloride Chemical Structure

Benzetimide hydrochloride Chemical Structure

CAS No. : 5633-14-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 38 In-stock
Solution
10 mM * 1 mL in DMSO USD 38 In-stock
Solid
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25 mg USD 80 In-stock
50 mg USD 120 In-stock
100 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

Benzetimide hydrochloride Related Antibodies

Top Publications Citing Use of Products

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

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Description

Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist. Target: mAChR

Molecular Weight

398.93

Formula

C23H27ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1CCN(CC2=CC=CC=C2)CC1)(C3=CC=CC=C3)CC4)NC4=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (80.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 16.67 mg/mL (41.79 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5067 mL 12.5335 mL 25.0671 mL
5 mM 0.5013 mL 2.5067 mL 5.0134 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.44%

COA (260 KB) HNMR (186 KB) LCMS (311 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5067 mL 12.5335 mL 25.0671 mL 62.6676 mL
5 mM 0.5013 mL 2.5067 mL 5.0134 mL 12.5335 mL
10 mM 0.2507 mL 1.2534 mL 2.5067 mL 6.2668 mL
15 mM 0.1671 mL 0.8356 mL 1.6711 mL 4.1778 mL
20 mM 0.1253 mL 0.6267 mL 1.2534 mL 3.1334 mL
25 mM 0.1003 mL 0.5013 mL 1.0027 mL 2.5067 mL
30 mM 0.0836 mL 0.4178 mL 0.8356 mL 2.0889 mL
40 mM 0.0627 mL 0.3133 mL 0.6267 mL 1.5667 mL
DMSO 50 mM 0.0501 mL 0.2507 mL 0.5013 mL 1.2534 mL
60 mM 0.0418 mL 0.2089 mL 0.4178 mL 1.0445 mL
80 mM 0.0313 mL 0.1567 mL 0.3133 mL 0.7833 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Benzetimide hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzetimide5633-14-7R4929R 4929R-4929mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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