2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK9-IN-8

CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.

For research use only. We do not sell to patients.

CDK9-IN-8 Chemical Structure

CDK9-IN-8 Chemical Structure

CAS No. : 2105956-51-0

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5 mg USD 280 In-stock
10 mg USD 400 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CDK9-IN-8 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

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Description

CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.

IC50 & Target[1]

CDK9

12 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
456 nM
Compound: 4d
Growth inhibition of human A549 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human A549 cells incubated for 72 hrs by CCK8 assay
[PMID: 28651979]
MCF7 IC50
338 nM
Compound: 4d
Growth inhibition of human MCF7 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human MCF7 cells incubated for 72 hrs by CCK8 assay
[PMID: 28651979]
NCI-H1299 IC50
221 nM
Compound: 4d
Growth inhibition of human H1299 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human H1299 cells incubated for 72 hrs by CCK8 assay
[PMID: 28651979]
NCI-H460 IC50
359 nM
Compound: 4d
Growth inhibition of human H460 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human H460 cells incubated for 72 hrs by CCK8 assay
[PMID: 28651979]
T47D IC50
358 nM
Compound: 4d
Growth inhibition of human T47D cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human T47D cells incubated for 72 hrs by CCK8 assay
[PMID: 28651979]
Molecular Weight

569.63

Formula

C31H32FN7O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC=C(NC(C2(CC2)C(NC3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(N(C)C)=O)=C5)=N4)C=C3)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 5.2 mg/mL (9.13 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7555 mL 8.7776 mL 17.5553 mL
5 mM 0.3511 mL 1.7555 mL 3.5111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7555 mL 8.7776 mL 17.5553 mL 43.8881 mL
5 mM 0.3511 mL 1.7555 mL 3.5111 mL 8.7776 mL
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CDK9-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-82105956-51-0CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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