2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Chlorpheniramine maleate

Chlorpheniramine maleate  (Synonyms: Chlorphenamine maleate)

Cat. No.: HY-B0286A Purity: 99.90%
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Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM.

For research use only. We do not sell to patients.

Chlorpheniramine maleate Chemical Structure

Chlorpheniramine maleate Chemical Structure

CAS No. : 113-92-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 28 In-stock
Solution
10 mM * 1 mL in DMSO USD 28 In-stock
Solid
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5 g USD 40 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Chlorpheniramine maleate:

Chlorpheniramine maleate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].

IC50 & Target

H1 Receptor

 

In Vitro

Chlorpheniramine maleate shows antimalarial activity against P. falciparum (IC50: 61.2 and 3.9 μM for D6 and Dd2 strain)[2].
Chlorpheniramine maleate reduces the proton currents (IC50: 43 μM) in BV2 microglial cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorpheniramine maleate Related Antibodies
In Vivo

Chlorpheniramine maleate (10 mg/kg, p.o) inhibits scratching in Ovalbumin (HY-W250978)-challenged BALB/c mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

390.86

Formula

C20H23ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (255.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 33.33 mg/mL (85.27 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5585 mL 12.7923 mL 25.5846 mL
5 mM 0.5117 mL 2.5585 mL 5.1169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 120 mg/mL (307.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5585 mL 12.7923 mL 25.5846 mL 63.9615 mL
5 mM 0.5117 mL 2.5585 mL 5.1169 mL 12.7923 mL
10 mM 0.2558 mL 1.2792 mL 2.5585 mL 6.3962 mL
15 mM 0.1706 mL 0.8528 mL 1.7056 mL 4.2641 mL
20 mM 0.1279 mL 0.6396 mL 1.2792 mL 3.1981 mL
25 mM 0.1023 mL 0.5117 mL 1.0234 mL 2.5585 mL
30 mM 0.0853 mL 0.4264 mL 0.8528 mL 2.1321 mL
40 mM 0.0640 mL 0.3198 mL 0.6396 mL 1.5990 mL
50 mM 0.0512 mL 0.2558 mL 0.5117 mL 1.2792 mL
60 mM 0.0426 mL 0.2132 mL 0.4264 mL 1.0660 mL
80 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7995 mL
DMSO 100 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.6396 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Chlorpheniramine maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorpheniramine113-92-8ChlorphenamineHistamine ReceptorInhibitorinhibitorinhibit

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