Cyclo(RGDyK) trifluoroacetate

Name: Cyclo(RGDyK) trifluoroacetate
Brand: MedChemExpress
SKU: HY-100563
Rating: 5.0 (3 reviews)

Cat. No.: HY-100563 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cyclo(RGDyK) trifluoroacetate is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(RGDyK) trifluoroacetate Chemical Structure

CAS No. : 250612-42-1

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5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 890	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Cyclo(RGDyK) trifluoroacetate:

Cyclo(RGDyK) Get quote

3 Publications Citing Use of MCE Cyclo(RGDyK) trifluoroacetate

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cyclo(RGDyK) trifluoroacetate is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.

IC₅₀ & Target

αvβ3

20 nM (IC₅₀)

In Vitro

Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for α_Vβ₃ over α_Vβ₅ (IC₅₀=4000 nM) and α_IIbβ₃ (IC₅₀=3000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

847.72

Formula

C₃₁H₄₃F₆N₉O₁₂

CAS No.

250612-42-1

Appearance

Solid

Color

White to off-white

Sequence Shortening

RGDYK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (117.96 mM; Need ultrasonic)

DMSO : 100 mg/mL (117.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1796 mL	5.8982 mL	11.7963 mL
5 mM	0.2359 mL	1.1796 mL	2.3593 mL
10 mM	0.1180 mL	0.5898 mL	1.1796 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.17 mg/mL (2.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.17 mg/mL (2.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.17 mg/mL (2.56 mM); Clear solution; Need warming

This protocol yields a clear solution of 2.17 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (280 KB) SDS (562 KB)

COA (258 KB) RP-HPLC (257 KB) Elemental Analysis Report (118 KB)

Handling Instructions (2659 KB)

References

[1]. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.1796 mL	5.8982 mL	11.7963 mL	29.4909 mL
	5 mM	0.2359 mL	1.1796 mL	2.3593 mL	5.8982 mL
	10 mM	0.1180 mL	0.5898 mL	1.1796 mL	2.9491 mL
	15 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9661 mL
	20 mM	0.0590 mL	0.2949 mL	0.5898 mL	1.4745 mL
	25 mM	0.0472 mL	0.2359 mL	0.4719 mL	1.1796 mL
	30 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.9830 mL
	40 mM	0.0295 mL	0.1475 mL	0.2949 mL	0.7373 mL
	50 mM	0.0236 mL	0.1180 mL	0.2359 mL	0.5898 mL
	60 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.4915 mL
	80 mM	0.0147 mL	0.0737 mL	0.1475 mL	0.3686 mL
	100 mM	0.0118 mL	0.0590 mL	0.1180 mL	0.2949 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.