2. Autophagy Metabolic Enzyme/Protease Apoptosis
  3. Autophagy Mitophagy Endogenous Metabolite Ferroptosis
  4. D-Glutamine

D-Glutamine is a cell-permeable D type stereoisomer of Glutamine.

For research use only. We do not sell to patients.

D-Glutamine Chemical Structure

D-Glutamine Chemical Structure

CAS No. : 5959-95-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in Water USD 66 In-stock
Solid
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100 mg USD 78 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of D-Glutamine:

D-Glutamine Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

D-Glutamine is a cell-permeable D type stereoisomer of Glutamine.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools[1].
D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Glutamine Related Antibodies
Molecular Weight

146.14

Formula

C5H10N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@H](CCC(N)=O)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (136.86 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : 4 mg/mL (27.37 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8428 mL 34.2138 mL 68.4275 mL
5 mM 1.3686 mL 6.8428 mL 13.6855 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 12.5 mg/mL (85.53 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (244 KB) HNMR (236 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[2]

Effect of D-Glutamine and glutaminase inhibitor on acetaldehyde-induced permeability. Caco-2 cell monolayers are incubated for 4 h without or with acetaldehyde (600 μM) and L-Glutamine or D-Glutamine (2 mM) in the absence or presence of 6-diazo-5-oxo-L-norleucine (DON). Transepithelial electrical resistance (TER) and FITC-inulin flux are measured. Values are means±SE (n=6)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.8428 mL 34.2138 mL 68.4275 mL 171.0688 mL
5 mM 1.3686 mL 6.8428 mL 13.6855 mL 34.2138 mL
10 mM 0.6843 mL 3.4214 mL 6.8428 mL 17.1069 mL
15 mM 0.4562 mL 2.2809 mL 4.5618 mL 11.4046 mL
20 mM 0.3421 mL 1.7107 mL 3.4214 mL 8.5534 mL
25 mM 0.2737 mL 1.3686 mL 2.7371 mL 6.8428 mL
H2O 30 mM 0.2281 mL 1.1405 mL 2.2809 mL 5.7023 mL
40 mM 0.1711 mL 0.8553 mL 1.7107 mL 4.2767 mL
50 mM 0.1369 mL 0.6843 mL 1.3686 mL 3.4214 mL
60 mM 0.1140 mL 0.5702 mL 1.1405 mL 2.8511 mL
80 mM 0.0855 mL 0.4277 mL 0.8553 mL 2.1384 mL
100 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7107 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Glutamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Glutamine5959-95-5AutophagyMitophagyEndogenous MetaboliteFerroptosisMitochondrial AutophagyInhibitorinhibitorinhibit

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