2. Anti-infection
  3. Bacterial Antibiotic
  4. Finafloxacin

Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments.

For research use only. We do not sell to patients.

Finafloxacin Chemical Structure

Finafloxacin Chemical Structure

CAS No. : 209342-40-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 324 In-stock
Solution
10 mM * 1 mL in DMSO USD 341 In-stock
Solid
5 mg USD 310 In-stock
10 mg USD 495 In-stock
50 mg USD 1400 In-stock
100 mg USD 1950 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Finafloxacin:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Finafloxacin

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Description

Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. Target: Antibacterial Finafloxacin is a pH-activated fluoroquinolone (belonging to a new 8-cyano subclass) to treat serious bacterial infections associated with an acidic environment, including urinary tract infections (UTIs) and Helicobacter pylori infections. Finafloxacin exhibits optimal efficacy in slightly acidic environments (pH 5.0-6.0), under which other fluoroquinolones lose activity. Finafloxacin is highly selective for bacterial type II topoisomerases, including DNA gyrase and DNA topoisomerase IV. [1]

IC50 & Target

Quinolone

 

Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT00723502MerLion Pharmaceuticals GmbH
Gram-Negative Bacterial Infections|Helicobacter Infections|Dyspepsia
September 2008Phase 2
NCT01907867MerLion Pharmaceuticals GmbH
Safety and Tolerability
January 2012Phase 1
NCT01928433MerLion Pharmaceuticals GmbH
Urinary Tract Infections|Acute Pyelonephritis
December 2012Phase 2
Molecular Weight

398.39

Formula

C20H19FN4O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@]5([H])OCCN[C@@]5([H])C4)=C3C#N)C1=O)O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 6.4 mg/mL (16.06 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5101 mL 12.5505 mL 25.1010 mL
5 mM 0.5020 mL 2.5101 mL 5.0202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5101 mL 12.5505 mL 25.1010 mL 62.7526 mL
5 mM 0.5020 mL 2.5101 mL 5.0202 mL 12.5505 mL
10 mM 0.2510 mL 1.2551 mL 2.5101 mL 6.2753 mL
15 mM 0.1673 mL 0.8367 mL 1.6734 mL 4.1835 mL
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Finafloxacin Related Classifications

Keywords:

Finafloxacin209342-40-5BacterialAntibioticInhibitorinhibitorinhibit

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