2. Cytoskeleton
  3. Gap Junction Protein
  4. Danegaptide Hydrochloride

Danegaptide Hydrochloride  (Synonyms: GAP-134 Hydrochloride; ZP 1609 Hydrochloride)

Cat. No.: HY-10913A Purity: 99.49%
COA Handling Instructions

Molarity Calculator

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect.

For research use only. We do not sell to patients.

Danegaptide Hydrochloride Chemical Structure

Danegaptide Hydrochloride Chemical Structure

CAS No. : 943133-81-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solution
10 mM * 1 mL in DMSO USD 154 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 220 In-stock
25 mg USD 440 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Danegaptide Hydrochloride:

Danegaptide Hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Danegaptide Hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].

IC50 & Target

Gap junction.
In Vitro

Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danegaptide Hydrochloride Related Antibodies
In Vivo

Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl2[1].
? Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

327.76

Formula

C14H18ClN3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 55 mg/mL (167.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (152.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0510 mL 15.2551 mL 30.5101 mL
5 mM 0.6102 mL 3.0510 mL 6.1020 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (305.10 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.49%

COA (251 KB) HNMR (145 KB) RP-HPLC (169 KB) LCMS (327 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.0510 mL 15.2551 mL 30.5101 mL 76.2753 mL
5 mM 0.6102 mL 3.0510 mL 6.1020 mL 15.2551 mL
10 mM 0.3051 mL 1.5255 mL 3.0510 mL 7.6275 mL
15 mM 0.2034 mL 1.0170 mL 2.0340 mL 5.0850 mL
20 mM 0.1526 mL 0.7628 mL 1.5255 mL 3.8138 mL
25 mM 0.1220 mL 0.6102 mL 1.2204 mL 3.0510 mL
30 mM 0.1017 mL 0.5085 mL 1.0170 mL 2.5425 mL
40 mM 0.0763 mL 0.3814 mL 0.7628 mL 1.9069 mL
50 mM 0.0610 mL 0.3051 mL 0.6102 mL 1.5255 mL
60 mM 0.0509 mL 0.2543 mL 0.5085 mL 1.2713 mL
80 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.9534 mL
100 mM 0.0305 mL 0.1526 mL 0.3051 mL 0.7628 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Danegaptide Hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danegaptide943133-81-1GAP-134ZP 1609GAP134GAP 134ZP1609ZP-1609Gap Junction ProteinCardioprotectiveantiarrhythmicorallydipeptideInhibitorinhibitorinhibit

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