2. Epigenetics
  3. Epigenetic Reader Domain
  4. GSK-5959

GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC50 of ~ 80 nM.

For research use only. We do not sell to patients.

GSK-5959 Chemical Structure

GSK-5959 Chemical Structure

CAS No. : 901245-65-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 73 In-stock
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Solid
1 mg USD 26 In-stock
5 mg USD 66 In-stock
10 mg USD 110 In-stock
50 mg USD 319 In-stock
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Based on 1 publication(s) in Google Scholar

GSK-5959 Related Antibodies

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Description

GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC50 of ~ 80 nM[1].

IC50 & Target

IC50: 80 nM (BRPF1)[1].
In Vitro

GSK-5959 (3a) also displays selectivity over the closely related family members, BRPF2 (100-fold) and BRPF3 (>1000-fold)[2].
GSK-5959 (3a) exhibits an EC50 = 0.98 μM) in cellular NanoBRET assay[2].
GSK-5959 has no effect on TRIM24 SUMOylation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-5959 Related Antibodies
Molecular Weight

394.47

Formula

C22H26N4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 13 mg/mL (32.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5350 mL 12.6752 mL 25.3505 mL
5 mM 0.5070 mL 2.5350 mL 5.0701 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5350 mL 12.6752 mL 25.3505 mL 63.3762 mL
5 mM 0.5070 mL 2.5350 mL 5.0701 mL 12.6752 mL
10 mM 0.2535 mL 1.2675 mL 2.5350 mL 6.3376 mL
15 mM 0.1690 mL 0.8450 mL 1.6900 mL 4.2251 mL
20 mM 0.1268 mL 0.6338 mL 1.2675 mL 3.1688 mL
25 mM 0.1014 mL 0.5070 mL 1.0140 mL 2.5350 mL
30 mM 0.0845 mL 0.4225 mL 0.8450 mL 2.1125 mL
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GSK-5959 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-5959901245-65-6GSK5959GSK 5959Epigenetic Reader DomainBRPF1BRPF2BRD1BRPF3bromodomainepigeneticsInhibitorinhibitorinhibit

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