2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. K-Ras G12C-IN-1

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.

For research use only. We do not sell to patients.

K-Ras G12C-IN-1 Chemical Structure

K-Ras G12C-IN-1 Chemical Structure

CAS No. : 1629265-17-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 414 In-stock
Solution
10 mM * 1 mL in DMSO USD 414 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1950 In-stock
100 mg USD 3500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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K-Ras G12C-IN-1 Related Antibodies

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Description

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. IC50 value: Target: K-ras G12C inhibitor

Molecular Weight

448.34

Formula

C22H23Cl2N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C(OC)C(NCC(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC=CC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (89.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2305 mL 11.1523 mL 22.3045 mL
5 mM 0.4461 mL 2.2305 mL 4.4609 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.19%

COA (247 KB) HNMR (182 KB) LCMS (437 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2305 mL 11.1523 mL 22.3045 mL 55.7613 mL
5 mM 0.4461 mL 2.2305 mL 4.4609 mL 11.1523 mL
10 mM 0.2230 mL 1.1152 mL 2.2305 mL 5.5761 mL
15 mM 0.1487 mL 0.7435 mL 1.4870 mL 3.7174 mL
20 mM 0.1115 mL 0.5576 mL 1.1152 mL 2.7881 mL
25 mM 0.0892 mL 0.4461 mL 0.8922 mL 2.2305 mL
30 mM 0.0743 mL 0.3717 mL 0.7435 mL 1.8587 mL
40 mM 0.0558 mL 0.2788 mL 0.5576 mL 1.3940 mL
50 mM 0.0446 mL 0.2230 mL 0.4461 mL 1.1152 mL
60 mM 0.0372 mL 0.1859 mL 0.3717 mL 0.9294 mL
80 mM 0.0279 mL 0.1394 mL 0.2788 mL 0.6970 mL
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K-Ras G12C-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras G12C-IN-11629265-17-3RasInhibitorinhibitorinhibit

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