2. Membrane Transporter/Ion Channel
  3. BCRP
  4. KS176

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.

For research use only. We do not sell to patients.

KS176 Chemical Structure

KS176 Chemical Structure

CAS No. : 1253452-78-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 88 In-stock
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 138 In-stock
25 mg USD 290 In-stock
50 mg USD 481 In-stock
100 mg USD 800 In-stock
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Based on 2 publication(s) in Google Scholar

KS176 Related Antibodies

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Description

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay). Target: BCRP The more detailed information please refer to Compound 9 in the reference.

Molecular Weight

405.40

Formula

C22H19N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=CC=C1)NC3=CC=C(CCO)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (86.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4667 mL 12.3335 mL 24.6670 mL
5 mM 0.4933 mL 2.4667 mL 4.9334 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4667 mL 12.3335 mL 24.6670 mL 61.6675 mL
5 mM 0.4933 mL 2.4667 mL 4.9334 mL 12.3335 mL
10 mM 0.2467 mL 1.2333 mL 2.4667 mL 6.1667 mL
15 mM 0.1644 mL 0.8222 mL 1.6445 mL 4.1112 mL
20 mM 0.1233 mL 0.6167 mL 1.2333 mL 3.0834 mL
25 mM 0.0987 mL 0.4933 mL 0.9867 mL 2.4667 mL
30 mM 0.0822 mL 0.4111 mL 0.8222 mL 2.0556 mL
40 mM 0.0617 mL 0.3083 mL 0.6167 mL 1.5417 mL
50 mM 0.0493 mL 0.2467 mL 0.4933 mL 1.2333 mL
60 mM 0.0411 mL 0.2056 mL 0.4111 mL 1.0278 mL
80 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
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KS176 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS1761253452-78-6KS 176KS-176BCRPBreast cancer resistance proteinABCG2Inhibitorinhibitorinhibit

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