Lidanserin (Synonyms: ZK-33839)

Cat. No.: HY-101815 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lidanserin (ZK-33839) acts as a 5-HT_2A and α₁-adrenergic receptor antagonist.

For research use only. We do not sell to patients.

Lidanserin Chemical Structure

CAS No. : 73725-85-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1210	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1210	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1780	Get quote	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Lidanserin (ZK-33839) acts as a 5-HT_2A and α₁-adrenergic receptor antagonist.

IC₅₀ & Target^[1]

5-HT_2A Receptor

α1-adrenergic receptor

In Vitro

Lidanserin is a combined 5-HT_2A and α₁-adrenergic receptor antagonist. Lidanserin is uaed as an antihypertensive agent.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.53

Formula

C₂₆H₃₁FN₂O₄

CAS No.

73725-85-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NCC(C2=CC=C(OC)C(OCCCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)=C2)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (110.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2001 mL	11.0004 mL	22.0007 mL
5 mM	0.4400 mL	2.2001 mL	4.4001 mL
10 mM	0.2200 mL	1.1000 mL	2.2001 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (243 KB) HNMR (271 KB) MS (122 KB)

Handling Instructions (2659 KB)

References

[1]. Boichenko I, et al. Chemical Ligand Space of Cereblon. ACS Omega. 2018 Sep 14;3(9):11163-11171. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2001 mL	11.0004 mL	22.0007 mL	55.0019 mL
	5 mM	0.4400 mL	2.2001 mL	4.4001 mL	11.0004 mL
	10 mM	0.2200 mL	1.1000 mL	2.2001 mL	5.5002 mL
	15 mM	0.1467 mL	0.7334 mL	1.4667 mL	3.6668 mL
	20 mM	0.1100 mL	0.5500 mL	1.1000 mL	2.7501 mL
	25 mM	0.0880 mL	0.4400 mL	0.8800 mL	2.2001 mL
	30 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8334 mL
	40 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3750 mL
	50 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1000 mL
	60 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9167 mL
	80 mM	0.0275 mL	0.1375 mL	0.2750 mL	0.6875 mL
	100 mM	0.0220 mL	0.1100 mL	0.2200 mL	0.5500 mL

Lidanserin Related Classifications

Neurological Disease Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lidanserin73725-85-6ZK-33839ZK33839ZK 338395-HT ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta ReceptorInhibitorinhibitorinhibit

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