2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Luseogliflozin

Luseogliflozin  (Synonyms: TS 071)

Cat. No.: HY-10449 Purity: 99.20%
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Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM). Luseogliflozin has the protential for researching type 2 diabetes.

For research use only. We do not sell to patients.

Luseogliflozin Chemical Structure

Luseogliflozin Chemical Structure

CAS No. : 898537-18-3

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Based on 1 publication(s) in Google Scholar

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Luseogliflozin Related Antibodies

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SGLT1 SGLT2

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Description

Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM). Luseogliflozin has the protential for researching type 2 diabetes[1][2].

IC50 & Target[1]

SGLT2

2.26 nM (IC50)

SGLT1

3990 nM (IC50)

In Vitro

Luseogliflozin competitively inhibits the sodium-dependent uptake of 14C-α-methylglucoside by Chinese hamster ovary K1 cells overexpressing human SGLT2 in vitro (Ki value 1.10 nM)[1].
Luseogliflozin (20% OSI-096 (HY-10191) and Luseogliflozin-generated serum, 24 h) induces β-cell proliferation through a humoral factor-mediated FoxM1/PLK1/CENP-A pathway independent of insulin signaling[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Luseogliflozin Related Antibodies

Real Time qPCR[2]

Cell Line: β cell
Concentration: 20% OSI-096 and Luseogliflozin-generated serum
Incubation Time: 24 h
Result: Promoted β-cell proliferation and significantly increased gene expression levels of Foxm1, Cenpa, Plk1 and Ccnb1.
In Vivo

Luseogliflozin (10 mg/kg, oral, 7 days) improves hyperglycemia and promotes β-cell proliferation in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male mice induced by OSI-906[2]
Dosage: 10 mg/kg/daily, 7 days
Administration: Oral
Result: Inhibited SGLT2 and significantly improved hyperglycemia in mice, but did not improve hyperinsulinemia.Had no effect on hepatic steatosis and adipose tissue atrophy, and improved the quality and proliferation of β cells.
Clinical Trial
Molecular Weight

434.55

Formula

C23H30O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](S1)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1C2=C(OC)C=C(C)C(CC3=CC=C(OCC)C=C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Luseogliflozin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luseogliflozin898537-18-3TS 071TS071TS-071SGLTSodium-dependent glucose cotransportersType 2 diabetesOrally activeInhibitorinhibitorinhibit

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