MOMIPP

Name: MOMIPP
Brand: MedChemExpress
SKU: HY-119624
Rating: 4.5 (1 reviews)

Cat. No.: HY-119624 Purity: 99.37%: FAQs
Data Sheet SDS COA Handling Instructions

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MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

MOMIPP Chemical Structure

CAS No. : 1363421-46-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 457	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 457	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 142	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	5.02 μM Compound: 1; MOMIPP	Antiproliferative activity against human A375 cells after 48 hrs by MTS assay Antiproliferative activity against human A375 cells after 48 hrs by MTS assay	[PMID: 29878764]
A549	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human A549 cells after 48 hrs by MTS assay Antiproliferative activity against human A549 cells after 48 hrs by MTS assay	[PMID: 29878764]
BGC-823	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay	[PMID: 29878764]
HCT-116	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay	[PMID: 29878764]
HepG2	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay	[PMID: 29878764]
MCF-10A	IC₅₀	> 10 μM Compound: 1; MOMIPP	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29878764]
MCF7	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay	[PMID: 29878764]
MDA-MB-231	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay	[PMID: 29878764]
MDA-MB-435S	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay	[PMID: 29878764]
SK-MEL-28	IC₅₀	8.156 μM Compound: 1; MOMIPP	Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay	[PMID: 29878764]
SK-MEL-30	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay	[PMID: 29878764]
U-251	IC₅₀	1.9 μM Compound: 19, MOMIPP	Cytotoxicity against human U251 cells after 24 hrs by MTT assay Cytotoxicity against human U251 cells after 24 hrs by MTT assay	[PMID: 22335538]
U-251	GI₅₀	2.1 μM Compound: 1, MOMIPP	Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay	[PMID: 24527179]
U-251	GI₅₀	2.3 μM Compound: 1a	Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis	[PMID: 27343855]
U-251	GI₅₀	2.32 μM Compound: 1a	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay	[PMID: 27343855]
U-251	GI₅₀	2.32 μM Compound: 1a, MOMIPP	Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay	[PMID: 25654321]

In Vitro

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations^[1].
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization^[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	U251 cells
Concentration:	10 μM
Incubation Time:	4 h or 24 h
Result:	Activated the JNK stress kinase pathway.

In Vivo

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)^[2]
Dosage:	80 mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

Molecular Weight

292.33

Formula

C₁₈H₁₆N₂O₂

CAS No.

1363421-46-8

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(/C=C/C1=C(NC2=C1C=C(C=C2)OC)C)C3=CC=NC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4208 mL	17.1040 mL	34.2079 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.37%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) HNMR (260 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411. [Content Brief]

[2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4208 mL	17.1040 mL	34.2079 mL	85.5198 mL
	5 mM	0.6842 mL	3.4208 mL	6.8416 mL	17.1040 mL
	10 mM	0.3421 mL	1.7104 mL	3.4208 mL	8.5520 mL
	15 mM	0.2281 mL	1.1403 mL	2.2805 mL	5.7013 mL
	20 mM	0.1710 mL	0.8552 mL	1.7104 mL	4.2760 mL
	25 mM	0.1368 mL	0.6842 mL	1.3683 mL	3.4208 mL
	30 mM	0.1140 mL	0.5701 mL	1.1403 mL	2.8507 mL
	40 mM	0.0855 mL	0.4276 mL	0.8552 mL	2.1380 mL
	50 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.7104 mL
	60 mM	0.0570 mL	0.2851 mL	0.5701 mL	1.4253 mL
	80 mM	0.0428 mL	0.2138 mL	0.4276 mL	1.0690 mL
	100 mM	0.0342 mL	0.1710 mL	0.3421 mL	0.8552 mL

MOMIPP Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOMIPP1363421-46-8PIKfyveFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1MacropinocytosisBBBJNK1/2c-JunBcl-2Bcl-xLInhibitorinhibitorinhibit

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