Mebhydrolin

Name: Mebhydrolin
Brand: MedChemExpress
SKU: HY-B1303A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1303A Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions

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Mebhydrolin is a specific histamine H₁ receptor antagonist.

For research use only. We do not sell to patients.

Mebhydrolin Chemical Structure

CAS No. : 524-81-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 53	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 53	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 48	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Mebhydrolin:

Mebhydrolin napadisylate In-stock

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mebhydrolin is a specific histamine H₁ receptor antagonist.

IC₅₀ & Target

Histamine H1-receptor^[1]

In Vitro

Mebhydrolin is a specific histamine H₁-receptor antagonist and comparing it with the effects of chlorpromazine, the archetypical phenothiazine^[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.38

Formula

C₁₉H₂₀N₂

CAS No.

524-81-2

Appearance

Solid

Color

White to off-white

SMILES

CN(C1)CCC(N2CC3=CC=CC=C3)=C1C4=C2C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (180.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6182 mL	18.0910 mL	36.1821 mL
5 mM	0.7236 mL	3.6182 mL	7.2364 mL
10 mM	0.3618 mL	1.8091 mL	3.6182 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (257 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7. [Content Brief]

[2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6182 mL	18.0910 mL	36.1821 mL	90.4552 mL
	5 mM	0.7236 mL	3.6182 mL	7.2364 mL	18.0910 mL
	10 mM	0.3618 mL	1.8091 mL	3.6182 mL	9.0455 mL
	15 mM	0.2412 mL	1.2061 mL	2.4121 mL	6.0303 mL
	20 mM	0.1809 mL	0.9046 mL	1.8091 mL	4.5228 mL
	25 mM	0.1447 mL	0.7236 mL	1.4473 mL	3.6182 mL
	30 mM	0.1206 mL	0.6030 mL	1.2061 mL	3.0152 mL
	40 mM	0.0905 mL	0.4523 mL	0.9046 mL	2.2614 mL
	50 mM	0.0724 mL	0.3618 mL	0.7236 mL	1.8091 mL
	60 mM	0.0603 mL	0.3015 mL	0.6030 mL	1.5076 mL
	80 mM	0.0452 mL	0.2261 mL	0.4523 mL	1.1307 mL
	100 mM	0.0362 mL	0.1809 mL	0.3618 mL	0.9046 mL

Mebhydrolin Related Classifications

Inflammation/Immunology Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mebhydrolin524-81-2Histamine ReceptorInhibitorinhibitorinhibit

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Mebhydrolin

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Other Forms of Mebhydrolin:

Mebhydrolin Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Mebhydrolin Related Antibodies

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Complete Stock Solution Preparation Table

Mebhydrolin Related Classifications

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