2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Anti-infection
  3. ADC Cytotoxin DNA/RNA Synthesis Antibiotic Bacterial
  4. N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin  (Synonyms: N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin)

Cat. No.: HY-19791 Purity: 99.17%
COA Handling Instructions

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N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC.

For research use only. We do not sell to patients.

N-Acetyl-Calicheamicin Chemical Structure

N-Acetyl-Calicheamicin Chemical Structure

CAS No. : 108212-76-6

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1 mg USD 600 In-stock
5 mg USD 1500 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Acetyl-Calicheamicin:

N-Acetyl-Calicheamicin Related Antibodies

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Description

N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].

In Vitro

N-Acetyl-Calicheamicin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1]
Once the ADC is internalized and degraded in the lysosome, the potent calicheamicin derivative, N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), is then activated by reduction of the dimethyl disulfide trigger in the cytosol to form the potent enediyne diradical capable of inducing DNA strand breaks[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetyl-Calicheamicin Related Antibodies
Molecular Weight

1410.39

Formula

C57H76IN3O22S4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSSC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (70.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7090 mL 3.5451 mL 7.0902 mL
5 mM 0.1418 mL 0.7090 mL 1.4180 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.39%

COA (258 KB) RP-HPLC (299 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7090 mL 3.5451 mL 7.0902 mL 17.7256 mL
5 mM 0.1418 mL 0.7090 mL 1.4180 mL 3.5451 mL
10 mM 0.0709 mL 0.3545 mL 0.7090 mL 1.7726 mL
15 mM 0.0473 mL 0.2363 mL 0.4727 mL 1.1817 mL
20 mM 0.0355 mL 0.1773 mL 0.3545 mL 0.8863 mL
25 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7090 mL
30 mM 0.0236 mL 0.1182 mL 0.2363 mL 0.5909 mL
40 mM 0.0177 mL 0.0886 mL 0.1773 mL 0.4431 mL
50 mM 0.0142 mL 0.0709 mL 0.1418 mL 0.3545 mL
60 mM 0.0118 mL 0.0591 mL 0.1182 mL 0.2954 mL
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N-Acetyl-Calicheamicin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyl-Calicheamicin108212-76-6N-Acetyl-Calicheamicin γ N-Acetyl-γ-calicheamicinADC CytotoxinDNA/RNA SynthesisAntibioticBacterialADC Payloadenediyneanti-tumor antibioticDNA damageADC cytotoxinInhibitorinhibitorinhibit

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