2. Immunology/Inflammation
  3. P-selectin
  4. PSI-697

PSI-697  (Synonyms: P-Selectin Inhibitor)

Cat. No.: HY-15526 Purity: 99.73%
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PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.

For research use only. We do not sell to patients.

PSI-697 Chemical Structure

PSI-697 Chemical Structure

CAS No. : 851546-61-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 340 In-stock
Solution
10 mM * 1 mL in DMSO USD 340 In-stock
Solid
1 mg USD 168 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 7 publication(s) in Google Scholar

PSI-697 Related Antibodies

Top Publications Citing Use of Products

    PSI-697 purchased from MedChemExpress. Usage Cited in: Chem Eng J. 382 (2020) 122848.

    Localization of NPs in H22 bearing tumor tissues. Mice bearing H22 tumors are intravenously injected with PLTM-HMnO2@Cur NPs and PSI-697 pre-treated (20 μg mL-1, 1 h) PLTM-HMnO2@Cur NPs. 24 h later, the tumors were removed and sectioned under frozen conditions followed by staining with an antibody against CD44 (green).

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    Description

    PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].

    IC50 & Target

    IC50: 125 μM (P-selectin)[1]
    In Vitro

    PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PSI-697 Related Antibodies
    In Vivo

    PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].
    PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
    PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
    PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4-5 weeks male Sprague-Dawley rat (50-100 g)[1]
    Dosage: 0 mg/kg, 30 mg/kg, 50 mg/kg
    Administration: Oral administration
    Result: At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.
    Clinical Trial
    Molecular Weight

    367.83

    Formula

    C21H18ClNO3
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 45.8 mg/mL (124.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7186 mL 13.5932 mL 27.1865 mL
    5 mM 0.5437 mL 2.7186 mL 5.4373 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.73%

    COA (255 KB) RP-HPLC (245 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7186 mL 13.5932 mL 27.1865 mL 67.9662 mL
    5 mM 0.5437 mL 2.7186 mL 5.4373 mL 13.5932 mL
    10 mM 0.2719 mL 1.3593 mL 2.7186 mL 6.7966 mL
    15 mM 0.1812 mL 0.9062 mL 1.8124 mL 4.5311 mL
    20 mM 0.1359 mL 0.6797 mL 1.3593 mL 3.3983 mL
    25 mM 0.1087 mL 0.5437 mL 1.0875 mL 2.7186 mL
    30 mM 0.0906 mL 0.4531 mL 0.9062 mL 2.2655 mL
    40 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
    50 mM 0.0544 mL 0.2719 mL 0.5437 mL 1.3593 mL
    60 mM 0.0453 mL 0.2266 mL 0.4531 mL 1.1328 mL
    80 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8496 mL
    100 mM 0.0272 mL 0.1359 mL 0.2719 mL 0.6797 mL
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    PSI-697 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PSI-697851546-61-7P-Selectin InhibitorPSI697PSI 697P-selectinCD62Inhibitorinhibitorinhibit

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