Propionylcarnitine

Cat. No.: HY-113092: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency.

For research use only. We do not sell to patients.

Propionylcarnitine Chemical Structure

CAS No. : 17298-37-2

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 99	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO	USD 99	Ask For Quote & Lead Time
Solid
5 mg	USD 90	Ask For Quote & Lead Time
10 mg	USD 160	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Propionylcarnitine:

Propionyl-L-carnitine Get quote
Propionyl-DL-carnitine chloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Propionylcarnitine shows protection to beta-thalassaemic erythrocytes from oxidative stress^[3].
Propionylcarnitine increases production of ¹⁴CO₂ from [1-¹⁴C]pyruvate and increases the rate of formation of acetyl camitine from pyruvate^[4].
Propionylcarnitine allows the endothelial cells to maintain their functionality and regulatory role on vessel activity for a longer time and decreases the formation of oxygen reactive species due to xanthine oxidase activity on hypoxanthine formed by adenine nucleotide catabolism^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Propionylcarnitine (2 mM/kg; p.o. for 4 weeks) affects plasma and urine total carnitine concentrations of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult age-matched male C57BL/6 mice^[5]
Dosage:	2 mM/kg/day
Administration:	Oral gavage; 2 mM/kg/day for 4 weeks
Result:	Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.

Molecular Weight

217.26

Formula

C₁₀H₁₉NO₄

CAS No.

17298-37-2

Appearance

Solid

SMILES

CCC(OC(CC([O-])=O)C[N+](C)(C)C)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (575.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (460.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6028 mL	23.0139 mL	46.0278 mL
5 mM	0.9206 mL	4.6028 mL	9.2056 mL
10 mM	0.4603 mL	2.3014 mL	4.6028 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (9.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (248 KB) HNMR (255 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Jacobs PL, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 2009;6:9. Published 2009 Apr 2. [Content Brief]

[2]. Kowal A, et al. Propionylcarnitine and methionine concentrations in newborns with hypospadias. Cent European J Urol. 2013;66(3):377-380. [Content Brief]

[3]. Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. [Content Brief]

[4]. Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. [Content Brief]

[5]. Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. [Content Brief]

[6]. Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.6028 mL	23.0139 mL	46.0278 mL	115.0695 mL
	5 mM	0.9206 mL	4.6028 mL	9.2056 mL	23.0139 mL
	10 mM	0.4603 mL	2.3014 mL	4.6028 mL	11.5070 mL
	15 mM	0.3069 mL	1.5343 mL	3.0685 mL	7.6713 mL
	20 mM	0.2301 mL	1.1507 mL	2.3014 mL	5.7535 mL
	25 mM	0.1841 mL	0.9206 mL	1.8411 mL	4.6028 mL
	30 mM	0.1534 mL	0.7671 mL	1.5343 mL	3.8357 mL
	40 mM	0.1151 mL	0.5753 mL	1.1507 mL	2.8767 mL
	50 mM	0.0921 mL	0.4603 mL	0.9206 mL	2.3014 mL
	60 mM	0.0767 mL	0.3836 mL	0.7671 mL	1.9178 mL
	80 mM	0.0575 mL	0.2877 mL	0.5753 mL	1.4384 mL
	100 mM	0.0460 mL	0.2301 mL	0.4603 mL	1.1507 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.