1. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  2. Drug Metabolite PDGFR
  3. Regorafénib N-oxyde (M2)

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

For research use only. We do not sell to patients.

Regorafénib N-oxyde (M2) Chemical Structure

Regorafénib N-oxyde (M2) Chemical Structure

CAS No. : 835621-11-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO In-stock
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Molecular Weight

498.81

Formula

C21H15ClF4N4O4

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (100.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0048 mL 10.0239 mL 20.0477 mL
5 mM 0.4010 mL 2.0048 mL 4.0095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.32%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0048 mL 10.0239 mL 20.0477 mL 50.1193 mL
5 mM 0.4010 mL 2.0048 mL 4.0095 mL 10.0239 mL
10 mM 0.2005 mL 1.0024 mL 2.0048 mL 5.0119 mL
15 mM 0.1337 mL 0.6683 mL 1.3365 mL 3.3413 mL
20 mM 0.1002 mL 0.5012 mL 1.0024 mL 2.5060 mL
25 mM 0.0802 mL 0.4010 mL 0.8019 mL 2.0048 mL
30 mM 0.0668 mL 0.3341 mL 0.6683 mL 1.6706 mL
40 mM 0.0501 mL 0.2506 mL 0.5012 mL 1.2530 mL
50 mM 0.0401 mL 0.2005 mL 0.4010 mL 1.0024 mL
60 mM 0.0334 mL 0.1671 mL 0.3341 mL 0.8353 mL
80 mM 0.0251 mL 0.1253 mL 0.2506 mL 0.6265 mL
100 mM 0.0200 mL 0.1002 mL 0.2005 mL 0.5012 mL
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Product Name:
Regorafénib N-oxyde (M2)
Cat. No.:
HY-I0678
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