2. PROTAC MAPK/ERK Pathway Autophagy
  3. PROTACs p38 MAPK Autophagy
  4. SJFα

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM.

For research use only. We do not sell to patients.

SJFα Chemical Structure

SJFα Chemical Structure

CAS No. : 2254609-27-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 604 In-stock
Solution
10 mM * 1 mL in DMSO USD 604 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 490 In-stock
25 mg USD 1020 In-stock
50 mg USD 1800 In-stock
100 mg USD 3100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

SJFα Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

IC50 & Target[1]

p38α

7.16 nM (DC50)

p38δ

299 nM (DC50)

VHL

 

Molecular Weight

1120.27

Formula

C59H67F2N7O11S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (89.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8926 mL 4.4632 mL 8.9264 mL
5 mM 0.1785 mL 0.8926 mL 1.7853 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.61%

COA (244 KB) HNMR (415 KB) LCMS (274 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8926 mL 4.4632 mL 8.9264 mL 22.3160 mL
5 mM 0.1785 mL 0.8926 mL 1.7853 mL 4.4632 mL
10 mM 0.0893 mL 0.4463 mL 0.8926 mL 2.2316 mL
15 mM 0.0595 mL 0.2975 mL 0.5951 mL 1.4877 mL
20 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1158 mL
25 mM 0.0357 mL 0.1785 mL 0.3571 mL 0.8926 mL
30 mM 0.0298 mL 0.1488 mL 0.2975 mL 0.7439 mL
40 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.5579 mL
50 mM 0.0179 mL 0.0893 mL 0.1785 mL 0.4463 mL
60 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3719 mL
80 mM 0.0112 mL 0.0558 mL 0.1116 mL 0.2790 mL
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SJFα Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJFα2254609-27-1PROTACsp38 MAPKAutophagyInhibitorinhibitorinhibit

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