2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

Related Products

PDF 0.84 MB

Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W012399
    2,5-Di-tert-butylhydroquinone
    		Modulator 99.90%
    2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) .
    2,5-Di-tert-butylhydroquinone
  • HY-W009248
    Phenethyl ferulate
    		Inhibitor 99.88%
    Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 4.35 μM and 5.75 μM, respectively.
    Phenethyl ferulate
  • HY-106200
    CJ-13,610
    		Inhibitor 98.01%
    CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC50 of about 70 nM. PMNL: polymorphonuclear leukocytes; AA: arachidonic acid
    CJ-13,610
  • HY-N6079
    Timosaponin A1
    		Inhibitor 99.24%
    Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively.
    Timosaponin A1
  • HY-127170
    3-Hydroxycoumarin
    		Inhibitor 99.30%
    3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage.
    3-Hydroxycoumarin
  • HY-121585
    CAY10698
    		Inhibitor 99.28%
    CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2.
    CAY10698
  • HY-101051
    2-TEDC
    		Inhibitor 99.55%
    2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC50 values of 0.09 μM, 0.013 μM and 0.5 μM, respectively. 2-TEDC can be used for the research of atheroscrelosi.
    2-TEDC
  • HY-W010144
    Phenidone
    		Inhibitor 99.00%
    Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Phenidone is used as a photographic developer.
    Phenidone
  • HY-119822
    Texasin
    		Inhibitor 99.51%
    Texasin is a natural product that can be isolated from Baptisia australis.
    Texasin
  • HY-133159
    Resolvin E2
    		Ligand
    Resolvin E2 ((-)-Resolvin E2), a proresolving lipid mediator, is useful as a lead for anti-inflammatory agent.
    Resolvin E2
  • HY-N9834
    Aureusidin
    		Inhibitor
    Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects.
    Aureusidin
  • HY-N7162
    3-O-Acetyl-11-hydroxy-beta-boswellic acid
    		Inhibitor 98.98%
    3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor.
    3-O-Acetyl-11-hydroxy-beta-boswellic acid
  • HY-138939
    5-LOX-IN-2
    		Inhibitor 98.75%
    5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research.
    5-LOX-IN-2
  • HY-130675A
    15(S)-HEPE
    		≥99.0%
    15(S)-HEPE is a monohydroxy fatty acid. 15(S)-HEPE is biosynthesized from eicosapentaenoic acid by 15-lipoxygenase (15-LO). Serum levels of 15(S)-HEPE are elevated in patients with asthma.
    15(S)-HEPE
  • HY-N2074
    Picrinine
    		Inhibitor 99.33%
    Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.
    Picrinine
  • HY-119671
    BW 755C
    		Inhibitor
    BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively.
    BW 755C
  • HY-N8276
    Ro 3-1314
    		Inhibitor ≥99.0%
    Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments.
    Ro 3-1314
  • HY-148134
    5-LOX-IN-1
    		Inhibitor 98.04%
    5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation.
    5-LOX-IN-1
  • HY-U00022
    RWJ 63556
    		Inhibitor 99.35%
    RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
    RWJ 63556
  • HY-101587
    (E)-KME-4
    		Inhibitor 99.51%
    (E)-KME-4 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
    (E)-KME-4
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

5-LOX

12-LOX

15-LOX

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Lipoxygenase Inhibitors, Antagonists & Modulators
Product Name5-LOX12-LOX15-LOXPurity    
U-73122
5-LOX
  99.79%
Zileuton
5-LOX
  99.61%
Caffeic acid
5-LO
  99.92%
Nordihydroguaiaretic acid
5-LOX, IC50: 8 μM
  99.93%
Canniprene
5-LO, IC50: 0.4 μM
  ≥98.0%
Wedelolactone
5-LOX, IC50: 2.5 μM
  99.91%
ML355 
12-LOX, IC50: 0.34 μM
 98.11%
Psoralidin
5-LOX
  99.90%
Indirubin-3'-monoxime
5-LOX, IC50: 7.8-10 μM
  99.76%
Licofelone
5-LOX, IC50: 0.18 μM
  99.84%
Pectolinarigenin
5-LOX
  99.79%
Osavampator
5-LO
  99.89%
β-Boswellic acid
5-LO
  99.89%
15-LOX-1 inhibitor 1  
15-LOX-1, IC50: 0.19 μM
98.60%
Malotilate
5-Lipoxygenase, IC50: 4.7 μM
  99.47%
11-​Keto-​beta-​boswellic acid
5-LOX
  99.96%
Cirsiliol
5-Lipoxygenase
  99.26%
S-(+)-Marmesin
5-LOX
  99.04%
Docebenone
5-LO
  99.31%
PF-4191834
5-LOX
  99.77%
5-O-Demethylnobiletin
5-LOX, IC50: 0.1 μM
  99.91%
Zileuton sodium
5-Lipoxygenase
  98.61%
2,5-Di-tert-butylhydroquinone
5-LO, IC50: 1.8 μM
  99.90%
Phenethyl ferulate
5-LOX, IC50: 5.75 μM
  99.88%
Timosaponin A1
5-Lipoxygenase, IC50: 3.29 μM
  99.24%
3-O-Acetyl-11-hydroxy-beta-boswellic acid
5-LOX
  98.98%
5-LOX-IN-2
5-LOX, IC50: 0.33 μM
  98.75%
Picrinine
5-Lipoxygenase
  99.33%
BW 755C
5-LO, IC50: 5 μM
  
RWJ 63556
5-Lipoxygenase
  99.35%
(E)-KME-4
5-Lipoxygenase, IC50: 1.05 μM
  99.51%
Tebufelone
5-LO
  99.52%
Lonapalene
5-LO
  99.45%
Damnacanthol  
15-LOX
99.76%
5-LOX-IN-4
5-Lipoxygenase
  98.07%
Enazadrem
5-Lipoxygenase
  
COX-2/15-LOX-IN-6  
15-LOX, IC50: 11.723 μM
LY256548
5-LOX
  
NCTT-956 
12-LOX
 
15-LOX-IN-1  
15-LOX, IC50: 1.92 μM
Caffeoylcalleryanin  
15-LOX, IC50: 1.59 μM
mPGES-1/5-LOX-IN-1
5-LOX, IC50: 1.89 μM
  
5-LOX-IN-6
5-LO
  
β-Boswellic acid (Standard)
5-LO
  
COX-2/15-LOX-IN-1  
15-LOX, IC50: 2.98 μM
Lipoxygenin
5-LO, IC50: 5 μM
  
EP6
5-Lipoxygenase, IC50: 0.05 μM
  
5-LO/mPGES1-IN-1
5-LOX, IC50: 0.4 μM
  
Lycopodine
5-Lipoxygenase
  
ICI 211965
5-LPO
  
Linetastine
5-Lipoxygenase
  
L 670630
5-Lipoxygenase, IC50: 23 nM
  
LY 178002
5-LPO, IC50: 0.6 μM
  
Sigmoidin B
5-Lipoxygenase
  
15-LOX-IN-2  
15-LOX, IC50: 5.87 μM
Ferroleuton
5-LOX, IC50: 0.21 μM
  
Atreleuton
5-LO
  
A-69412
5-LO
  
Ruthenoleuton
5-LOX, IC50: 3.49 μM
5-LOX, Ki: 0.80 μM
  
COX-2/5-LOX-IN-3
5-LOX, IC50: 4.33 μM
  
CBS-1114 hydrochloride
5-Lipoxygenase
  
BLX-3887  
15-LOX-1, IC50: 32 nM
BF389
5-LOX
  
LP117
5-LO, IC50: 1.1 μM
  
ZLJ-6
5-LOX, IC50: 0.99 μM
  
S-2474
5-LO
  
FerroLOXIN-1
5-LOX
  
CMI977
5-LO
  
COX/5-LO-IN-1
5-LO, IC50: 2 μM
  
CMI-392
5-LO, IC50: 100 nM
  
AZD 4407
5-Lipoxygenase
  
Bunaprolast
5-LO