Lipoxygenase

Lipoxygenase Related Products (141):

By Effects:	Substrate (1) Inhibitors (120) Ligand (1) Antagonist (1) Modulators (2)

Cat. No.	Product Name	Effect	Purity

HY-133215

Zileuton sulfoxide	Inhibitor
Zileuton sulfoxide is a sulfoxide derivative of Zileuton (HY-14164), a potent and selective inhibitor of lipoxygenase 5-LOX with anti-asthmatic properties.

HY-119086

L-651392	Inhibitor
L-651392 is an orally active and specific 5-lipoxygenase inhibitor that inhibits the production of leukotrienes. L-651392 controls the inflammatory process in Escherichia coli pyelonephritis by preventing inflammatory cells from reaching the site of infection and protecting the renal tubules from inflammation-related damage during pyelonephritis.

HY-116164

A-79175	Inhibitor
A-79175 is a potent 5-lipoxygenase inhibitor that inhibits leukotriene formation. A-79175 is promising for research of various allergic and inflammatory diseases including asthma, allergic rhinitis, rheumatoid arthritis and inflammatory bowel disease.

HY-113691

(E)-L-652343
(E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer.

HY-118848

A63162	Inhibitor
A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease.

HY-117853S

Atreleuton-d₄	Inhibitor
Atreleuton-d₄ (ABT-761-d₄; VIA-2291-d₄) is deuterium-labeled Atreleuton (HY-117853).

HY-N2056R

11-Keto-beta-boswellic acid (Standard)	Inhibitor
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

HY-161907

h15-LOX-2 inhibitor 2	Inhibitor
h15-LOX-2 inhibitor 2 (Compound 10) is an inhibitor of h15-LOX, with IC₅₀ and K_i values of 26.9 μM and 16.4 μM, respectively.

HY-19023

L-651896	Inhibitor
L-651896 is a compound with anti-inflammatory and antiproliferative activities that inhibits 5-lipoxygenase and cyclooxygenase, thereby reducing the production of leukotrienes and prostaglandins. L-651896 can be used in the study of skin diseases and other inflammatory diseases.

HY-123391

PD 127443	Inhibitor
PD 127443 is an inhibitor of 5-lipoxygenase and cyclooxygenase. PD 127443 has anti-inflammatory activity.

HY-N3073

Picralinal	Inhibitor
Picralinal (Picraline, 16-de(acetoxymethyl)-16-formyl-) is a Triterpenoids product that can be isolated from the whole plants of Scilla scilloides..

HY-169138

ZD 2138	Inhibitor
ZD 2138 is an inhibitor of 5-lipoxygenase. ZD-2138 can alleviate bronchoconstriction induced by aspirin (HY-14654) and can be used in asthma research.

HY-155244

12R-LOX-IN-2	Inhibitor	99.85%
12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases.

HY-120721

Lagunamycin	Inhibitor
Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.

HY-117784

BI-L-357	Inhibitor
BI-L-357 is a succinate derived from BI-L-226 that acts as a precursor, enhances oral bioavailability and inhibits 5-lipoxygenase-mediated leukotriene production.

HY-14164S1

Zileuton-¹³C₂,¹⁵N	Inhibitor
Zileuton-¹³C₂,¹⁵N is ¹⁵N and ¹³C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.

HY-W706470

(-)-Bornyl ferulate	Inhibitor
(-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor with IC₅₀s of 10.4 μM and 12.0 μM, respectively.

HY-114830

Fenleuton	Inhibitor
Fenleuton is a 5-lipoxygenase inhibitor. Fenleuton is promising for research of leukotriene-mediated inflammatory diseases.

HY-W028263

6-Hydroxyflavanone	Inhibitor
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes.

HY-116080

SB 210661	Inhibitor
SB 210661 is a potent and selective 5-lipoxygenase inhibitor.

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