2. Signaling Pathways
  3. Neuronal Signaling
  4. Amyloid-β

Amyloid-β

β-amyloid peptide; Aβ; Abeta

Amyloid-β

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Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5946
    β-Amyloid (1-8)
    β-Amyloid (1-8) is aAβ Fragment.
    β-Amyloid (1-8)
  • HY-P4885
    Glp-amyloid-β (3-40) peptide (human)
    Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice.
    Glp-amyloid-β (3-40) peptide (human)
  • HY-B0104S3
    Glimepiride-d4-2
    		Inhibitor
    Glimepiride-d4-2 (GliAmperide-d4-2) is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
    Glimepiride-d<sub>4</sub>-2
  • HY-N0615R
    Notoginsenoside R1 (Standard)
    		Inhibitor
    Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.
    Notoginsenoside R1 (Standard)
  • HY-P4637
    Ile-Phe
    Ile-Phe is a dipeptide that self-associates in aqueous solution to form a transparent thermoreversible gel formed by a network of fibrillar nanostructures. It may be involved in triggering self-assembly processes such as amyloid formation.
    Ile-Phe
  • HY-W594851
    Biphenyl-3′,3,4,4′-tetrol
    		Inhibitor
    Biphenyl-3′,3,4,4′-tetrol (BPT) is a potent Aβ40 aggregation inhibitor. Biphenyl-3′,3,4,4′-tetrol (BPT) can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Biphenyl-3′,3,4,4′-tetrol
  • HY-P5968
    [Ala28]-β Amyloid(25-35)
    [Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electrically neutral mutant peptide of Aβ(25-35) that accelerates the aggregation of Firefly Luciferase.
    [Ala28]-β Amyloid(25-35)
  • HY-N12360
    2,3-Dehydrosilybin A
    		Inhibitor
    2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound.
    2,3-Dehydrosilybin A
  • HY-N2014R
    Verbenalin (Standard)
    		Inhibitor
    Verbenalin (Standard) is the analytical standard of Verbenalin. This product is intended for research and analytical applications. Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease.
    Verbenalin (Standard)
  • HY-10009R
    Semagacestat (Standard)
    		Inhibitor
    Semagacestat (Standard) is the analytical standard of Semagacestat. This product is intended for research and analytical applications. Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's?disease[1].
    Semagacestat (Standard)
  • HY-136674
    Aftin-5
    		Inducer
    Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively.
    Aftin-5
  • HY-P4886A
    Amyloid β-Protein (3-42) TFA
    		99.20%
    Amyloid β-Protein (3-42) TFA is a precursor of Pyr peptide. Pyroglutamic acid-modified Aβ (pEAβ) (3-42) is the core of the amyloid plaque in Alzheimer's disease. pEAβ (3-42) accelerates the aggregation of Aβ(1-42), while Aβ(1-42) significantly slows down the primary and secondary nucleation of pEAβ(3-42).
    Amyloid β-Protein (3-42) TFA
  • HY-112282
    BI-1408
    		Inhibitor
    BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42.
    BI-1408
  • HY-126192
    Pittsburgh Compound B
    		Ligand
    Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research.
    Pittsburgh Compound B
  • HY-N0695R
    Schisantherin B (Standard)
    		Inhibitor
    Schisantherin B (Standard) is the analytical standard of Schisantherin B. This product is intended for research and analytical applications. Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.
    Schisantherin B (Standard)
  • HY-P1468F1
    5-FAM-β-Amyloid (1-28)
    5-FAM-β-Amyloid (1-28) is afluorescently labeled β-Amyloid (1-28) (HY-P1468).
    5-FAM-β-Amyloid (1-28)
  • HY-N7046S
    Silybin B-d3
    		Inhibitor
    Silybin B-d3 (Silibinin B-d3) is deuterium labeled Silybin B. Silybin B (Silibinin B), a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate.
    Silybin B-d<sub>3</sub>
  • HY-P10494
    FEFEFKFK
    FEFEFKFK is an octapeptide that self-assembles into fibrillar structures. FEFEFKFK is able to form gels at concentrations greater than about 7 mg/mL. The self-assembly and gelation properties of FEFEFKFK help to understand the mechanism of amyloid fibril formation in protein misfolding diseases such as Alzheimer's disease and Parkinson's disease.
    FEFEFKFK
  • HY-P991101
    Anti-Amyloid Beta Antibody (scFv59)
    		Inhibitor
    Anti-Amyloid Beta Antibody (scFv59) is a human antibody expressed in CHO cells, targeting Amyloid-β. Anti-Amyloid Beta Antibody (scFv59) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Amyloid Beta Antibody (scFv59)
  • HY-B0914B
    10-Undecenoic acid (copper)
    		Inhibitor
    10-Undecenoic acid copper (Undecylenic acid copper) is an antifungal agent. 10-Undecenoic acid copper inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid copper has neuroprotective effects. 10-Undecenoic acid copper has anticancer effects on a variety of tumors. 10-Undecenoic acid copper inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid copper inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
    10-Undecenoic acid (copper)
Cat. No. Product Name / Synonyms Application Reactivity