Cathepsin

Cathepsin Related Products (149):

By Effects:	Control (1) Inhibitors (110) Agonist (1) Activators (3) Inducer (1)

Cat. No.	Product Name	Effect	Purity

HY-D0843

N-Ethylmaleimide	Inhibitor	99.89%
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC₅₀ value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides.

HY-18234A

Leupeptin hemisulfate	Inhibitor	99.39%
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity.

HY-B0496

PMSF	Inhibitor	99.32%
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates.

HY-148905

p-Aminophenylmercuric acetate	Activator	99.07%
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor.

HY-P1645

Papain
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-129578R

Asperphenamate (Standard)	Inhibitor
Asperphenamate (Standard) is the analytical standard of Asperphenamate. This product is intended for research and analytical applications. Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].

HY-172977

FGA139	Inhibitor
FGA139 is a cysteine proteases inhibitor with IC₅₀ values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research.

HY-172203

BI-1915	Inhibitor
BI-1915 is the selective inhibitor for Cathepsin S with an IC₅₀ of 17 nM. BI-1915 can be used in research of autoimmune diseases.

HY-100229

Aloxistatin	Inhibitor	99.94%
Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.

HY-16594

Lactacystin	Inhibitor	98.20%
Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC₅₀ = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on^[2]^[6].

HY-W011063

Gly-Phe-β-naphthylamide		99.90%
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C.

HY-103351

Cathepsin G Inhibitor I	Inhibitor	≥99.0%
Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC₅₀=53 nM; K_i=63 nM).

HY-100231

Cathepsin inhibitor 1	Inhibitor	99.28%
Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC₅₀s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis.

HY-134434

Z-Arg-Arg-AMC hydrochloride		99.79%
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B.

HY-D0843S

N-Ethylmaleimide-d₅	Inhibitor	99.90%
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor.

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride	Inhibitor	98.63%
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity.

HY-118355

ALLM	Inhibitor	98.60%
ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

HY-112818

S130	Inhibitor	99.43%
S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC₅₀ of 3.24 µM. S130 suppresses autophagy flux.

HY-146985

Cathepsin X-IN-1	Inhibitor	99.62%
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC₅₀ of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic.

HY-P1759B

N-CBZ-Phe-Arg-AMC TFA		99.95%
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.

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