2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. E3 Ligase Ligand-Linker Conjugates Isoform

E3 Ligase Ligand-Linker Conjugates

 

E3 Ligase Ligand-Linker Conjugates Related Products (349):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145449
    CC-885-CH2-PEG1-NH-CH3 2722698-03-3 99.22%
    CC-885-CH2-PEG1-NH-CH3 is a neoDegrader that can be used in the synthesis of Antibody neoDegrader Conjugate (AnDC).
    CC-885-CH2-PEG1-NH-CH3
  • HY-145448
    MC-VC-PABC-amide-PEG1-CH2-CC-885 2722697-82-5 99.93%
    MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs).
    MC-VC-PABC-amide-PEG1-CH2-CC-885
  • HY-141431
    Cbl-b-IN-2 2503325-21-9
    Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent.
    Cbl-b-IN-2
  • HY-132208
    Pomalidomide 4'-PEG2-azide 2271036-45-2 99.30%
    Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pomalidomide 4'-PEG2-azide
  • HY-131872
    Pomalidomide-PEG2-COOH 2140807-17-4 99.87%
    Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
    Pomalidomide-PEG2-COOH
  • HY-163904
    (S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH
    (S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate of PROTAC NCOA4 degrader-1 (HY-163897), which can be used for the synthesis of PROTACs.
    (S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH
  • HY-168349
    (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
    (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the coupling conjugate of the E3 ubiquitin ligase ligand and linker for NX-2127 (HY-153220).
    (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
  • HY-169372
    (S,R,S)-AHPC-CO-C4-bromine 2162120-79-6
    (S,R,S)-AHPC-CO-C4-bromine is an E3 Ligase Ligand-linker Conjugate for PROTAC synthesis. (S,R,S)-AHPC-CO-C4-bromine is composed of an E3 Ligase Ligand (HY-125845) and a linker
    (S,R,S)-AHPC-CO-C4-bromine
  • HY-139345
    (S,R,S)-AHPC-CO-C9-acid 2172819-78-0
    (S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs.
    (S,R,S)-AHPC-CO-C9-acid
  • HY-139218
    (S,R,S)-AHPC-Me-C6-NH2 2411422-49-4 99.14%
    (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTAC. (S,R,S)-AHPC-Me-C6-NH2 (Compound SI-9) contains VHL ligand 2 (HY-112078).
    (S,R,S)-AHPC-Me-C6-NH2
  • HY-148896
    (S,R,S)-AHPC-C2-PEG3-BCN 2876198-36-4 99.22%
    (S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL ligand, and can be used for synthesis of PROTACs.
    (S,R,S)-AHPC-C2-PEG3-BCN
  • HY-148671
    (S,R,S)-AHPC-amido-C7-acid 2172819-76-8 98.28%
    (S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs.
    (S,R,S)-AHPC-amido-C7-acid
  • HY-W580022
    Pomalidomide-5'-PEG8-C2-COOH 2138440-78-3 98.21%
    Pomalidomide-5'-PEG8-C2-COOH is an E3 Ligase Ligand-Linker Conjugates, consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-5'-PEG8-C2-COOH can be used for synthesis of PROTACs.
    Pomalidomide-5'-PEG8-C2-COOH
  • HY-143348
    NJH-2-030 2709040-02-6 98.74%
    NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications.
    NJH-2-030
  • HY-133138
    Pomalidomide-PEG1-azide 2133360-04-8
    Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131). Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pomalidomide-PEG1-azide
  • HY-133139
    Lenalidomide-PEG1-azide 2185795-67-7
    Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136). Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Lenalidomide-PEG1-azide
  • HY-133699
    Pomalidomide-PEG4-COOH 2138440-81-8 ≥98.0%
    Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1).
    Pomalidomide-PEG4-COOH
  • HY-136184
    (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 2376990-26-8 99.01%
    (S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.
    (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride
  • HY-136183
    (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride 2376990-28-0 98.16%
    (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and an alkyl linker used for PROTAC degrader.
    (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride
  • HY-136772
    Pomalidomide-PEG1-NH2 hydrochloride 2380273-67-4
    Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand.
    Pomalidomide-PEG1-NH2 hydrochloride