MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

MALT1

Related Products

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.

MALT1 Inhibitors (29)

MALT1 Related Products (29)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-139399

Safimaltib	Inhibitor	99.89%
Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. Safimaltib in some cases lead to tumor stasis.

HY-12276

MALT1 inhibitor MI-2	Inhibitor	99.95%
MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC₅₀=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals.

HY-115466

MLT-748	Inhibitor	99.89%
MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC₅₀ of 5 nM.

HY-121282

Mepazine	Inhibitor	99.91%
Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC₅₀s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis.

HY-121282A

Mepazine hydrochloride	Inhibitor	99.94%
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC₅₀s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.

HY-121282B

Mepazine acetate	Inhibitor
Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1. Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL)-induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin. The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies.

HY-164560

MALT1-IN-14	Inhibitor
MALT1-IN-14 (comp 2) is a MALT1 inhibitor, with an IC₅₀ of 0.081 μM.

HY-134820

MLT-943	Inhibitor	99.77%
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. MLT-943 inhibits stimulated-IL-2 secretion in PBMC or in whole blood with a similar IC₅₀ across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood). MLT-943 has anti-inflammatory activities and can be used for FcgR-mediated inflammation research.

HY-142648

MLT-985	Inhibitor	99.34%
MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC₅₀ value of 3 nM.

HY-P1407

Z-VRPR-FMK TFA	Inhibitor
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection.

HY-131902

MLT-231	Inhibitor	99.55%
MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC₅₀ of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC₅₀ of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse.

HY-150232

MALT1-IN-11	Inhibitor
MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC₅₀ < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC₅₀ of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders.

HY-160698

SGR-1505	Inhibitor
SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas.

HY-124587

MLT-747	Inhibitor	99.56%
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC₅₀ of 14 nM.

HY-143427

MALT1-IN-9	Inhibitor
MALT1-IN-9 is a potent MALT1 protease inhibitor with a IC₅₀ of <500 nM in Raji MALT1-GloSensor cells. MALT1-IN-9 has anticancer effects (WO2021000855A1; Compound 5).

HY-120231

Z-VRPR-FMK	Inhibitor
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.

HY-143423

MALT1-IN-5	Inhibitor
MALT1-IN-5 (compound 1) is a potent MALT1 protease inhibitor. MALT1-IN-5 can be used for cancer research.

HY-143425A

(R)-MALT1-IN-7	Inhibitor
(R)-MALT1-IN-7 (compound 142a) is a potent MALT1 protease inhibitor. (R)-MALT1-IN-7 has the potential for cancer research.

HY-143422

MALT1-IN-3	Inhibitor
MALT1-IN-3 (compound 122) is a potent MALT1 protease inhibitor, with an IC₅₀ of 0.06 μM. MALT1-IN-3 has IC₅₀ of 0.14 and 0.13 μM for human IL6/IL10 in OCI-LY3 cells, respectively.

HY-142648A

(R)-MLT-985	Inhibitor
(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC₅₀ of 3 nM. (R)-MLT-985 has an IC₅₀ of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.

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MALT1

MALT1

MALT1 Related Products (29)

Antibodies (1)

MALT1 Related Products (29):