2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Y0202R
    Pyrocatechuic acid (Standard)
    Pyrocatechuic acid (Standard) is the analytical standard of Pyrocatechuic acid. This product is intended for research and analytical applications. Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.
    Pyrocatechuic acid (Standard)
  • HY-123033
    Nicotinamide riboside
    Nicotinamide riboside, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside
  • HY-113365S1
    Cholestenone-13C
    		≥99.0%
    Cholestenone-13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
    Cholestenone-<sup>13</sup>C
  • HY-B1342S
    Vitamin A-d8
    		98.39%
    Vitamin A-d8 is the deuterium labeled Vitamin A. Vitamin A is an endogenous metabolite.
    Vitamin A-d<sub>8</sub>
  • HY-Y1055S
    Guanine-13C
    		99.5%
    Guanine-13C is the 13C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
    Guanine-<sup>13</sup>C
  • HY-W011175
    Batilol
    		≥98.0%
    3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite.
    Batilol
  • HY-D0885D
    Phosphocreatine disodium hydrate
    		99.57%
    Phosphocreatine (disodium hydrate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium hydrate) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium hydrate) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium hydrate) Phosphocreatine (disodium hydrate) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway..
    Phosphocreatine disodium hydrate
  • HY-113046R
    5-Methyltetrahydrofolic acid (Standard)
    Alisol C 23-acetate (Standard) is the analytical standard of Alisol C 23-acetate. This product is intended for research and analytical applications. Alisol C 23-acetate is a natural product extracted from Alisma orientale, which can significantly reduce delayed-type hypersensitivity reactions.
    5-Methyltetrahydrofolic acid (Standard)
  • HY-W027555
    Ethoxyacetic acid
    		≥98.0%
    Ethoxyacetic acid is an endogenous metabolite.
    Ethoxyacetic acid
  • HY-N8357
    Vitamin D3 octanoate
    Vitamin D3 octanoate is an octanoate ester of vitamin D3. Vitamin D3 (Cholecalciferol; HY-15398) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
    Vitamin D3 octanoate
  • HY-N0322S3
    Cholesterol-13C5
    		99.5%
    Cholesterol-13C5 is the 13C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
    Cholesterol-<sup>13</sup>C<sub>5</sub>
  • HY-50723R
    3-Methylxanthine (Standard)
    3-Methylxanthine (Standard) is the analytical standard of 3-Methylxanthine. This product is intended for research and analytical applications. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
    3-Methylxanthine (Standard)
  • HY-E70290
    N-Acetylgalactosaminyltransferase 1
    N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3.
    N-Acetylgalactosaminyltransferase 1
  • HY-158292
    Digoxin-OVA
    Digoxin-OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Digoxin-OVA
  • HY-W015967R
    Glycolic acid (Standard)
    Glycolic acid (Standard) is the analytical standard of Glycolic acid. This product is intended for research and analytical applications. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
    Glycolic acid (Standard)
  • HY-N7092S8
    D-Fructose-d
    		≥98.0%
    D-Fructose-d is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
    D-Fructose-d
  • HY-W068783
    (E)-3,4-(Methylenedioxy)cinnamic acid
    		99.87%
    (E)-3,4-(Methylenedioxy)cinnamic acid is a cinnamic acid derivative obtained from the stem bark of Brombya platynema.
    (E)-3,4-(Methylenedioxy)cinnamic acid
  • HY-W011848
    Monobenzyl phthalate
    		≥98.0%
    Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP).
    Monobenzyl phthalate
  • HY-B2176C
    ATP dipotassium
    ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation.
    ATP dipotassium
  • HY-125770
    5(S)​-​HPETE
    		≥98.0%
    5(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 5-LO on arachidonic acid. 5(S)-HpETE is metabolized to leukotriene A4 (LTA4), a key intermediate in the formation of LTs.
    5(S)​-​HPETE
Cat. No. Product Name / Synonyms Application Reactivity