2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. I-191

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist.

For research use only. We do not sell to patients.

I-191 Chemical Structure

I-191 Chemical Structure

CAS No. : 1690172-25-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 266 In-stock
Solid
5 mg USD 242 In-stock
10 mg USD 363 In-stock
25 mg USD 605 In-stock
50 mg USD 902 In-stock
100 mg USD 1375 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

I-191 Related Antibodies

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PAR1 PAR2 PAR4

  • Biological Activity

  • Purity & Documentation

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Description

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

IC50 & Target

PAR2

 

In Vitro

I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

I-191 Related Antibodies
Molecular Weight

423.48

Formula

C23H26FN5O2
CAS No.
Appearance

Solid

Color

White to gray

SMILES

O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (2.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3614 mL 11.8069 mL 23.6139 mL
5 mM 0.4723 mL 2.3614 mL 4.7228 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.3614 mL 11.8069 mL 23.6139 mL 59.0347 mL
DMSO 5 mM 0.4723 mL 2.3614 mL 4.7228 mL 11.8069 mL
10 mM 0.2361 mL 1.1807 mL 2.3614 mL 5.9035 mL
15 mM 0.1574 mL 0.7871 mL 1.5743 mL 3.9356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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I-191 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I-1911690172-25-8I191I 191Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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