Ras

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison

Ras Related Products (501)
Antibodies (36)
Ras Isoform Comparison

By Effects:	Controls (7) Ligands (3) Inhibitors (416) Agonists (7) Degraders (17) Antagonists (3) Activators (20) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P10650

FAM49B (190-198) mouse	Inhibitor	99.76%
FAM49B (190-198) mouse is a peptide fragment of FAM49B. FAM49B is a mitochondria-localized protein that regulates mitochondrial fission. FAM49B regulates mitochondrial function and integrity and tumor progression. FAM49B is also a negative regulator in T cell activation, it acts by repressing GTPase Rac activity and modulating cytoskeleton reorganization.

HY-P10600A

BIMAX2 acetate	Inhibitor	98.95%
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence.

HY-162960

pan-KRAS degrader 1	Degrader
pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant K_i value of 25 nM for KRAS^G12V .pan-KRAS degrader 1 has antitumor activity.

HY-145915A

(E/Z)-ZINC09659342	Inhibitor	99.72%
(E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction.

HY-P3277A

KRpep-2d TFA	Inhibitor	98.11%
KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.

HY-114398A

(S)-BAY-293	Control
(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor.

HY-P10051A

Cyclorasin 9A5 TFA	Inhibitor	99.57%
Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC₅₀ of 120 nM.

HY-18605

K-Ras G12C-IN-2	Inhibitor	99.21%
K-Ras G12C-IN-2 is an irreversible covalent K-Ras G12C inhibitor.

HY-16111A

BMS-214662 hydrochloride	Inhibitor
BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase). BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC₅₀ value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras.

HY-12446

K-Ras(G12C) inhibitor 9	Inhibitor	≥98.0%
K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C).

HY-15872

FTI-277	Inhibitor
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

HY-N10336

Notoginsenoside R4		99.84%
Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3.

HY-15747A

Deltarasin hydrochloride	Inhibitor	98.07%
Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with K_d of 38 nM for binding to purified PDEδ.

HY-P10600

BIMAX2	Inhibitor
BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence.

HY-135864

KRAS inhibitor-6	Inhibitor
KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A.

HY-135866

KRAS inhibitor-8	Inhibitor
KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C.

HY-135865

KRAS inhibitor-7	Inhibitor
KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B.

HY-132920

KRAS mutant protein inhibitor 1	Inhibitor
KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential research in cancer.

HY-142487

KRAS G12C inhibitor 32	Inhibitor
KRAS G12C inhibitor 32, an eight membered heterocyclic compound containing N, is a potent KRAS G12C inhibitor.

HY-160866

(Rac)-D3S-001	Control
(Rac)-D3S-001 is the racemate of D3S-001 (HY-160023).

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Ras

Ras

Ras Isoform Specific Products:

Ras Isoform Specific Products:

Ras Related Products (501)

Antibodies (36)

Ras Isoform Comparison

Ras Related Products (501):