2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras

Ras

Ras

Related Products

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164529
    SJ-C1044
    		Inhibitor
    SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2/KDR/Flk-1, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer.
    SJ-C1044
  • HY-160220S
    KRAS inhibitor-23
    		Inhibitor
    KRAS inhibitor-23 (Isomer 2 of compound i) is a potent inhibitor of KRAS that plays an important role in cancer research.
    KRAS inhibitor-23
  • HY-119264
    PRLX-93936
    		Inhibitor
    PRLX-93936 dihydrochloride (Compound 16) is a HIF-1α inhibitor with anticancer activity. PRLX-93936 can inhibit the activated Ras pathway and can be used in the study of relapsed or refractory multiple myeloma.
    PRLX-93936
  • HY-120271
    GGTI-297
    		Inhibitor
    GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras.
    GGTI-297
  • HY-157067
    KRAS G12C inhibitor 62
    		Inhibitor
    KRAS G12C inhibitor 62 is a KRAS G12C inhibitor. KRAS G12C inhibitor 62 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021121367A1).
    KRAS G12C inhibitor 62
  • HY-123977
    RasGRP3 ligand 1
    		Activator
    RasGRP3 ligand 1 (compound 96) is a RasGRP3 ligand with a Ki of 1.75 nM. RasGRP3 ligand 1 can induce Ras activation and can be used for cancer research.
    RasGRP3 ligand 1
  • HY-B0105R
    Ketoconazole (Standard)
    		Inhibitor
    Ketoconazole (Standard) is the analytical standard of Ketoconazole. This product is intended for research and analytical applications. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole (Standard)
  • HY-50733
    CX-5011 free base
    		Activator
    CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation.
    CX-5011 free base
  • HY-114840
    L 731734
    		Inhibitor
    L 731734 is a prodrug of L-731735 (HY-129273), and inhibits Ras processing in cells transformed with v-ras.
    L 731734
  • HY-15136R
    Lonafarnib (Standard)
    		Inhibitor
    Lonafarnib (Standard) is the analytical standard of Lonafarnib. This product is intended for research and analytical applications. Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.
    Lonafarnib (Standard)
  • HY-120044
    L-739749
    L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro.
    L-739749
  • HY-120885
    (+)-Oxanthromicin
    		Modulator
    (+)-Oxanthromicin (Compound 1) mislocalizes the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells, and exhibits thereby antitumor efficacy.
    (+)-Oxanthromicin
  • HY-N14739
    Dykellic acid
    		Inhibitor
    Dykellic acid is a RhoA inhibitor. Dykellic acid can inhibit the migration and motility of B16 cells and the tube formation of HUVECs. Dykellic acid is promising for research of cancers.
    Dykellic acid
  • HY-164315
    KRAS G12C inhibitor 67
    		Inhibitor
    KRAS G12C inhibitor 67 (example 35) is a KRAS G12C inhibitor that selectively inhibits the growth of many KRAS G12C mutant tumor cell lines.
    KRAS G12C inhibitor 67
  • HY-158652
    (R)-CCG-1423
    (R)-CCG-1423 is an inhibitor of RhoA. (R)-CCG-1423 inhibits downstream of Rho and shows specificity for SRE.
    (R)-CCG-1423
  • HY-164389
    SML-10-70-1
    SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM.
    SML-10-70-1
  • HY-116664
    DPQZ
    		Inhibitor
    DPQZ is an anti-tubulin agent that inhibits cell separation and induces cell cycle arrest at the G2/M phase. In addition, DPQZ induces caspase-dependent apoptosis of HSC-3 cells by inhibiting Ras/Raf and activating MAP kinase. DPQZ can be used in the study of oral cancer.
    DPQZ
  • HY-168671
    pan-KRAS ligand 1
    		Inhibitor
    pan-KRAS ligand 1 is a Ligand for Target Protein for PROTAC. pan-KRAS ligand 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669).
    pan-KRAS ligand 1
  • HY-112541
    21-Hydroxyoligomycin A
    		Inhibitor
    21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC50 value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces.
    21-Hydroxyoligomycin A
  • HY-137641
    Sp-8-Br-2'-O-Me-cAMPS
    		Activator
    Sp-8-Br-2'-O-Me-cAMPS is a cAMP analog. Sp-8-Br-2'-O-Me-cAMPS is an activator of EPAC. Sp-8-Br-2'-O-Me-cAMPS can be used in metabolism-related studies.
    Sp-8-Br-2'-O-Me-cAMPS
Cat. No. Product Name / Synonyms Application Reactivity
Ras Isoform Comparison

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