2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. SGLT

SGLT

SGLT

Sodium-dependent glucose cotransporters

SGLT

Related Products

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SGLTs (Sodium-dependent glucose cotransporters) are a family of glucose transporters and contribute to glucose reabsorption. The two most well-known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family. The two transporters are of primary importance for glucose homeostasis by absorbing glucose from the diet in the small intestine (via SGLT1) and by reabsorbing the filtered glucose in the tubular system of the kidney (primarily SGLT2; to smaller extent via SGLT1); the latter process returns glucose into the blood stream and prevents urinary glucose loss. SGLT1 and SGLT2 have been proposed as a novel therapeutic strategy for diabetes and cardiomyopathy.

SGLT Isoform Specific Products:

SGLT Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114308
    SGL5213
    		Inhibitor
    SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. SGL5213 has potential to treat type 2 diabetes treatment.
    SGL5213
  • HY-15461S1
    Ertugliflozin-d9
    		Inhibitor
    Ertugliflozin-d9 is deuterated labeled Ertugliflozin (HY-15461). Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.
    Ertugliflozin-d<sub>9</sub>
  • HY-N0142R
    Phloretin (Standard)
    		Inhibitor
    Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively.Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.
    Phloretin (Standard)
  • HY-14810
    Atigliflozin
    Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC50s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus.
    Atigliflozin
  • HY-10451S2
    Canagliflozin-d6
    Canagliflozin-d6 is the deuterium labeled Canagliflozin[1]. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[2].
    Canagliflozin-d<sub>6</sub>
  • HY-109018A
    Velagliflozin proline
    		Inhibitor 99.43%
    Velagliflozin proline is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin proline reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations.
    Velagliflozin proline
  • HY-145357
    SGLT1/2-IN-2
    		Inhibitor
    SGLT1/2-IN-2 demonstrates potent dual inhibitory activities (IC50 = 96 nM for SGLT1 and IC50 = 1.3 nM for SGLT2).
    SGLT1/2-IN-2
  • HY-15461S
    Ertugliflozin-d5
    Ertugliflozin-d5 is the deuterium labeled Ertugliflozin[1]. Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[2]. Has the potential for the treatment of type 2 diabetes mellitus[3].
    Ertugliflozin-d<sub>5</sub>
  • HY-117010
    Kushenol K
    		Inhibitor
    Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2.
    Kushenol K
  • HY-106158
    T-1095
    		Inhibitor
    T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research.
    T-1095
  • HY-17638A
    Mizagliflozin (sebacate)
    		Inhibitor
    Mizagliflozin sebacate (DSP-3235 sebacate) is a sodium-glucose cotransporter inhibitor with activity in improving vascular cognitive impairment caused by small vessel disease. Mizagliflozin sebacate improves blood flow and reverses vascular cognitive impairment by inhibiting neuronal SGLT1 activity. Mizagliflozin sebacate also showed the ability to increase the survival rate of IL-1β-treated PC12HS cells. Mizagliflozin sebacate promotes improvements in spatial learning and memory caused by small vessel disease in mouse models.
    Mizagliflozin (sebacate)
  • HY-109018B
    Velagliflozin proline hydrate
    		Inhibitor 99.43%
    Velagliflozin proline hydrate is the clinical form of Velagliflozin (HY-109018). Velagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations.
    Velagliflozin proline hydrate
  • HY-12608
    TA-1887
    		Inhibitor
    TA-1887 (JNJ-39933673) is a highly potent, selective and orally active SGLT2 inhibitor (IC50: 1.4 nM) with antihyperglycemic effects. TA-1887 can be used in the research of diabetes.
    TA-1887
  • HY-10450AR
    Dapagliflozin ((2S)-1,2-propanediol, hydrate) (Standard)
    		Inhibitor
    Dapagliflozin ((2S)-1,2-propanediol, hydrate) (Standard) is the analytical standard of Dapagliflozin ((2S)-1,2-propanediol, hydrate). This product is intended for research and analytical applications. Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury.
    Dapagliflozin ((2S)-1,2-propanediol, hydrate) (Standard)
  • HY-122613
    YM543 free base
    		Inhibitor
    YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes.
    YM543 free base
  • HY-109092A
    rel-Licogliflozin
    		Inhibitor
    rel-Licogliflozin is a relative configuration of Licogliflozin (HY-109092). Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.
    rel-Licogliflozin
  • HY-N4100R
    Trilobatin (Standard)
    		Inhibitor
    Trilobatin (Standard) is the analytical standard of Trilobatin. This product is intended for research and analytical applications. Trilobatin, a natural sweetener derived from?Lithocarpus polystachyus?Rehd, Trilobatin?is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.
    Trilobatin (Standard)
  • HY-15461R
    Ertugliflozin (Standard)
    		Inhibitor
    Ertugliflozin (Standard) is the analytical standard of Ertugliflozin. This product is intended for research and analytical applications. Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.
    Ertugliflozin (Standard)
  • HY-10451R
    Canagliflozin (Standard)
    		Inhibitor
    Canagliflozin (Standard) is the analytical standard of Canagliflozin. This product is intended for research and analytical applications. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively.
    Canagliflozin (Standard)
  • HY-10450R
    Dapagliflozin (Standard)
    		Inhibitor
    Dapagliflozin (Standard) is the analytical standard of Dapagliflozin. This product is intended for research and analytical applications. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin induces HIF1 expression and attenuates renal IR injury.
    Dapagliflozin (Standard)
SGLT Isoform Comparison

SGLT1

SGLT2

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Please try each isoform separately.

SGLT Inhibitors
Product NameSGLT1SGLT2Purity    
Dapagliflozin 
SGLT2
99.97%
Canagliflozin 
SGLT2
99.69%
Phloretin
SGLT1
SGLT2
99.92%
Sotagliflozin
SGLT1
SGLT2
99.89%
Phlorizin
SGLT1
SGLT2
99.93%
Ertugliflozin 
SGLT2
99.92%
Ipragliflozin
hSGLT1, IC50: 1876 nM
rSGLT1, IC50: 1166 nM
mSGLT1, IC50: 1380 nM
hSGLT2, IC50: 7.38 nM
rSGLT2, IC50: 6.73 nM
mSGLT2, IC50: 5.64 nM
99.71%
Mizagliflozin
SGLT1
 98.87%
Dapagliflozin ((2S)-1,2-propanediol, hydrate) 
SGLT2
99.99%
Canagliflozin hemihydrate 
SGLT2
99.95%
Trilobatin
SGLT1
SGLT2
99.00%
Tofogliflozin hydrate 
SGLT2
98.48%
SGLT2-IN-1 
SGLT2, IC50: 33 nM
98.02%
Swertisin 
SGLT2
99.75%
Licogliflozin
SGLT1
SGLT2
≥98.0%
Velagliflozin 
SGLT2
99.92%
Dapagliflozin-d5 
SGLT2
98.01%
Ertugliflozin L-pyroglutamic acid 
SGLT2
99.84%
Remogliflozin etabonate
hSGLT1, Ki: 43.1 μM
rSGLT1, Ki: 8.57 μM
hSGLT2, Ki: 1.95 μM
rSGLT2, Ki: 2.14 μM
99.81%
Enavogliflozin 
SGLT2
98.01%
Ipragliflozin L-Proline 
SGLT2
99.94%
Luseogliflozin
SGLT1, IC50: 3990 nM
SGLT2, IC50: 2.26 nM
99.33%
Remogliflozin 
SGLT2
Sergliflozin etabonate 
SGLT2
99.64%
Canagliflozin-d4 
SGLT2
99.04%
SGLT1/2-IN-1
SGLT1, IC50: 15.72 mM
SGLT2, IC50: 3.67 mM
LX2761
SGLT1
SGLT2
Luseogliflozin hydrate 
SGLT2
99.20%
Phloretin (Standard)
SGLT1
SGLT2
Atigliflozin
hSGLT1, IC50: 8.2 μM
hSGLT2, IC50: 10 nM
Kushenol K
SGLT1
SGLT2
T-1095
hSGLT1, IC50: 22.8 μM
hSGLT2, IC50: 2.3 μM
Velagliflozin proline hydrate 
SGLT2
99.43%
TA-1887
SGLT1, IC50: 230 nM
SGLT2, IC50: 1.4 nM
YM543 free base 
SGLT2
TP0438836
hSGLT1, IC50: 28 nM
hSGLT2, IC50: 7 nM
galacto-Dapagliflozin
hSGLT1, Ki: 25000 nM
hSGLT2, Ki: 25 nM
fluoro-Dapagliflozin
hSGLT1, Ki: 330 nM
hSGLT2, Ki: 5.3 nM