2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING

STING

STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

Related Products

PDF 0.78 MB

Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139586B
    Ulevostinag (isomer 2)
    		Agonist
    Ulevostinag isomer 2 (MK-1454 isomer 2) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
    Ulevostinag (isomer 2)
  • HY-158711
    STING agonist-38
    		Agonist
    STING agonist-38 (compound 58) is a potent agonist of STING, with the EC50 of 0.05 μM in THP1 cells. STING agonist-38 has certain oral bioactivity.
    STING agonist-38
  • HY-149724
    Anti-inflammatory agent 65
    		Inhibitor
    Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response.
    Anti-inflammatory agent 65
  • HY-168803
    BDW-OH
    		Agonist
    BDW-OH is an active metabolite of BDW568 (HY-162465 ). BDW568 is a STING agonist that can selectively activate the human STINGA230 allele.
    BDW-OH
  • HY-164919
    Calotatug ginistinag
    		Agonist
    Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate targeting HER2, with an effective payload connected via a linker (LP, HY-148067) to a STING agonist (STING agonist-20, HY-148068), and has potential immune activation and anticancer activity.
    Calotatug ginistinag
  • HY-N15159
    Cladophorol A
    		Inhibitor
    Cladophorol A is a cGAS inhibitor that binds to the conserved adenosine nucleobase binding site of cGAS, thereby blocking its activity. At non-cytotoxic concentrations, Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A holds potential for research on inflammatory diseases related to the overactivation of the cGAS-STING pathway.
    Cladophorol A
  • HY-168384
    M04
    		Agonist
    M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases.
    M04
  • HY-163643
    STING modulator-7
    		Modulator
    STING modulator-7 (compound 132) is a modulator of STING,.
    STING modulator-7
  • HY-139586C
    Ulevostinag (isomer 3)
    		Agonist
    Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research.
    Ulevostinag (isomer 3)
  • HY-100941R
    CCCP (Standard)
    		Inhibitor
    CCCP (Standard) is the analytical standard of CCCP. This product is intended for research and analytical applications. CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
    CCCP (Standard)
  • HY-139586D
    Ulevostinag (isomer 4)
    		Agonist
    Ulevostinag isomer 4 (MK-1454 isomer 4) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
    Ulevostinag (isomer 4)
  • HY-N2616R
    Vomicine (Standard)
    		Inhibitor
    Vomicine (Standard) is the analytical standard of Vomicine. This product is intended for research and analytical applications. Vomicine modulates cGAS-STING-TBK1 signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds.
    Vomicine (Standard)
  • HY-W654000
    Cyclic GMP-13C,15N2
    		Activator
    Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators.
    Cyclic GMP-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-169483
    PDIC-NC
    		Agonist
    PDIC-NC is a STING agonist. PDIC-NC is cytotoxic to tumor cells and induces ROS explosion, apoptosis and autophagy. PDIC-NC has lung specific distribution and can be used in the study of lung cancer.
    PDIC-NC
Cat. No. Product Name / Synonyms Application Reactivity