2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING

STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

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Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12512
    cGAMP
    		Activator 99.22%
    cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP
  • HY-103665
    STING agonist-3
    		Agonist 99.94%
    STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
    STING agonist-3
  • HY-110382
    Cyclic-di-GMP disodium
    		Activator 99.23%
    Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
    Cyclic-di-GMP disodium
  • HY-107780B
    Cyclic-di-GMP diammonium
    		Activator 99.07%
    Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
    Cyclic-di-GMP diammonium
  • HY-123963
    C-178
    		Inhibitor 99.04%
    C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human.
    C-178
  • HY-147010
    STING agonist-12
    		Activator 98.63%
    STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.
    STING agonist-12
  • HY-19711
    STING agonist-1
    		Agonist 99.56%
    STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
    STING agonist-1
  • HY-150608
    PROTAC STING Degrader-1
    		Inhibitor 98.74%
    PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity.
    PROTAC STING Degrader-1
  • HY-152955
    STING agonist-22
    		Agonist 99.87%
    STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research.
    STING agonist-22
  • HY-130115A
    IACS-8803 disodium
    		Agonist 99.97%
    IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy.
    IACS-8803 disodium
  • HY-148068
    STING agonist-20
    		Agonist 99.75%
    STING agonist-20 (compound 95) is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases.
    STING agonist-20
  • HY-137320
    diABZI-C2-NH2
    		Agonist
    diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.
    diABZI-C2-NH2
  • HY-138683
    STING-IN-3
    		Inhibitor 99.86%
    STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.
    STING-IN-3
  • HY-W140974
    SN-001
    		Inhibitor 98.76%
    SN-001 is a STING inhibitor with an IC50 of 3.82 μM.
    SN-001
  • HY-111999A
    E7766 diammonium salt
    		Agonist 99.48%
    E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.
    E7766 diammonium salt
  • HY-157214
    NVS-STG2
    		Agonist 99.76%
    NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models.
    NVS-STG2
  • HY-123943
    STING agonist-4
    		Agonist 99.97%
    STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function.
    STING agonist-4
  • HY-141514
    MSA-2 dimer
    		Agonist 99.30%
    MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide.
    MSA-2 dimer
  • HY-148644
    STING-IN-6
    		Inhibitor 98.17%
    STING-IN-6 (compound 50) is a potent STING inhibitor with a pIC50 of 8.9. STING-IN-6 has the potential for immunity research.
    STING-IN-6
  • HY-156117
    LB244
    		Inhibitor 98.05%
    LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice.
    LB244
Cat. No. Product Name / Synonyms Application Reactivity