2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin
  5. Sirtuin Isoform

Sirtuin

 

Sirtuin Related Products (102):

Cat. No. Product Name Effect Purity
  • HY-119857
    AGK7
    AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease.
  • HY-156023
    Sirtuin modulator 7
    		Modulator 99.28%
    Sirtuin modulator 7 is a sirtuin-modulating compound which may increase the lifespan of a cell, and may be used for research of diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and flushing which would benefit from increased mitochondrial activity.
  • HY-163676
    MI-217
    		Inhibitor
    MI-217 is a potent SIRT3 inhibitor. MI-217 induces MDA-MB-231 apoptosis. MI-217 can be used in the study of breast cancer.
  • HY-169051
    SIRT-IN-5
    		Inhibitor
    SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ.
  • HY-149638
    HSP70/SIRT2-IN-2
    		Inhibitor
    HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity.
  • HY-136204
    Resveratrol analog 2
    		Agonist
    Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
  • HY-155729
    Sirt1/2-IN-4
    		Inhibitor
    Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity.
  • HY-RS12949
    Sirt5 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sirt5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS12954
    Sirt7 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-B0150S1
    Nicotinamide-15N,13C3
    		Inhibitor
    Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
  • HY-RS12944
    Sirt3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-163698
    SIRT-IN-4
    		Inhibitor
    SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC50=0.35 μM). SIRT-IN-4 is a potent Sirt2 deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study Sirt2 in cell cycle regulation, gene expression regulation, etc.
  • HY-158162
    SIRT3 activator 1
    		Activator
    SIRT3 activator 1 (Compound 5v) is a SIRT3 activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases.
  • HY-126904
    ZINC08792355
    		Inhibitor
    ZINC08792355 is a SIRT1 inhibitor and can be used for study of ageing, diabetes, and cancer..
  • HY-N0341R
    Scopolin (Standard)
    		Activator
    Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades.
  • HY-155988
    Sirtuin modulator 6
    		Modulator
    Sirtuin modulator 6 (compound 262) increases the lifespan of a cell. Sirtuin modulator 6 can be used for study of diabetes, obesity, neurodegenerative diseases, cardiovascular disease, and so an extracted from patent WO2009064913A1.
  • HY-136094
    SRT3657
    		Activator
    SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
  • HY-111317
    SIRT1 activator 3
    		Activator
    SIRT1 activator 3 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. SIRT1 activator 3 has the potential for anti-obesity or anti-diabetic researches.
  • HY-RS12953
    SIRT7 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT7 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-114981
    SRTCX1002
    		Activator
    SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively.