2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15811
    XMD8-87
    		Inhibitor 99.57%
    XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
    XMD8-87
  • HY-N2278
    Kushenol A
    		Inhibitor 99.84%
    Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.
    Kushenol A
  • HY-N2134
    Mirificin
    		Inhibitor 99.66%
    Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC50 of 12.66 μM.
    Mirificin
  • HY-N3518
    Mulberroside F
    		Inhibitor 99.37%
    Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.). Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation.
    Mulberroside F
  • HY-N2460
    Aloesin
    		Inhibitor 99.62%
    Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research.
    Aloesin
  • HY-W013636S2
    2-Ketoglutaric acid-d6
    		98.62%
    2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
    2-Ketoglutaric acid-d<sub>6</sub>
  • HY-W012595
    Benzylideneacetone
    		Inhibitor 99.66%
    Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A2 inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods.
    Benzylideneacetone
  • HY-N7929
    5-Feruloylquinic acid
    		Inhibitor 99.73%
    5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities.
    5-Feruloylquinic acid
  • HY-101243
    XMD16-5
    		Inhibitor 98.59%
    XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively.
    XMD16-5
  • HY-145587
    Paltimatrectinib
    		Inhibitor 99.96%
    Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases.
    Paltimatrectinib
  • HY-N1386
    2-Methoxycinnamic acid
    		Inhibitor 99.75%
    2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase.
    2-Methoxycinnamic acid
  • HY-N3516
    Oxyresveratrol 2-O-β-D-glucopyranoside
    		Inhibitor 99.08%
    Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC50 of 29.75 μM.
    Oxyresveratrol 2-O-β-D-glucopyranoside
  • HY-W013636R
    2-Ketoglutaric acid (standard)
    		Inhibitor 99.52%
    2-Ketoglutaric acid (Standard) is the analytical standard of 2-Ketoglutaric acid. This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid (standard)
  • HY-P99622
    Flanvotumab
    		Inhibitor
    Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance.
    Flanvotumab
  • HY-N1750
    3-(2,4-Dihydroxyphenyl)propanoic acid
    		Inhibitor 99.46%
    3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively.
    3-(2,4-Dihydroxyphenyl)propanoic acid
  • HY-W013636B
    Calcium 2-oxoglutarate
    		Inhibitor ≥98.0%
    Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).
    Calcium 2-oxoglutarate
  • HY-W013636A
    2-Ketoglutaric acid Sodium
    		Inhibitor ≥98.0%
    2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid Sodium
  • HY-D0168
    Orcinol
    		Inhibitor 99.97%
    Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases.
    Orcinol
  • HY-N4005
    Isoastilbin
    		Inhibitor 99.80%
    Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research.
    Isoastilbin
  • HY-P3662
    Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
    		Activator 99.95%
    Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.
    Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
Cat. No. Product Name / Synonyms Application Reactivity