2. Metabolic Enzyme/Protease
  3. Tyrosinase Endogenous Metabolite
  4. 2-Ketoglutaric acid Sodium

2-Ketoglutaric acid Sodium  (Synonyms: Alpha-Ketoglutaric acid Sodium)

Cat. No.: HY-W013636A Purity: ≥98.0%
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2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).

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2-Ketoglutaric acid Sodium Chemical Structure

2-Ketoglutaric acid Sodium Chemical Structure

CAS No. : 22202-68-2

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Based on 3 publication(s) in Google Scholar

Other Forms of 2-Ketoglutaric acid Sodium:

2-Ketoglutaric acid Sodium Related Antibodies

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Description

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

Microbial Metabolite

 

Tyrosinase

15 mM (IC50)

In Vitro

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
2-Ketoglutaric acid Sodium acts as precursor for the synthesis of amino acids and nucleotides[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Ketoglutaric acid Sodium Related Antibodies
Molecular Weight

168.08

Formula

C5H5NaO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C(CCC(O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5.88 mg/mL (34.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9495 mL 29.7477 mL 59.4955 mL
5 mM 1.1899 mL 5.9495 mL 11.8991 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.9495 mL 29.7477 mL 59.4955 mL 148.7387 mL
5 mM 1.1899 mL 5.9495 mL 11.8991 mL 29.7477 mL
10 mM 0.5950 mL 2.9748 mL 5.9495 mL 14.8739 mL
15 mM 0.3966 mL 1.9832 mL 3.9664 mL 9.9159 mL
20 mM 0.2975 mL 1.4874 mL 2.9748 mL 7.4369 mL
25 mM 0.2380 mL 1.1899 mL 2.3798 mL 5.9495 mL
30 mM 0.1983 mL 0.9916 mL 1.9832 mL 4.9580 mL
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2-Ketoglutaric acid Sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Ketoglutaric acid22202-68-2Alpha-Ketoglutaric acidTyrosinaseEndogenous MetaboliteintermediateprecursorTCAcarbonskeletonInhibitorinhibitorinhibit

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